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  Acetil-L-Carnitina Pro  
 
Articol: Acetil-L-Carnitina Pro
Compozitie: 250 mg Capsula
Prezentare: 1 Flacon cu 60 Capsule
Administrare: 1 - 2 Capsule pe zi
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3-5 buc.: 17.64
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Acetil-L-Carnitina Pro

1Acetil-L-Carnitina Acetil-L-Carnitina 200 mg 120 caps., o substanta proprie organismului, poate dona grupa de acetil in prezenta de Coenzima A pentru productia de acetilcolina un important neurotransmitator care creste capacitatea de memorare.

2Acetil-L-Carnitina Oamenii de stiinta au constatat efectul de crestere a neuritiilor prin mixtura de Acetil-L-Carntina (ALC) si L-Arginina cu 5,2% iar cu Acetil-L-Carnitina Arginat (ALCA)(19,5%) de 3,48 ori mai mult.


Anti Aging

Acetil_L_Carnitina

Acetil L-Carnitina Pro

Acetil_L_Carnitina

 

Acetil L-Carnitina cu efect Anti Aging
Acetil L-Carnitina cu efect Anti Aging

Acetil L-Carnitina-HCl: Structura chimica
Acetil L-Carnitina-HCl: Formula moleculara: C9H18ClNO4
Acetil L-Carnitina-HCl: Greutatea moleculara: 239.74

3Acetil-L-Carnitina Acetil-L-Carnitina un precursor de acetilcolina un important neurotransmitator care creste transmiterea influxului nervos intre sinapse

Acetilcolina-Neurotransmitator

Acetilcolina Neurotransmitator
Neuron Neurotransmitatorii transmit influxul nervos de la neuron spre neuriti (ramificati de dendrite si axon)
Neuron Neurotransmitatorii transmit influxul nervosAcetil-L-Carnitina

4Acetil-L-Carnitina Acetil-L-Carnitina este un optimizator de energie cerebrala si metabolismului de fosfolipide

5Acetil-L-Carnitina Acetil-L-Carnitina restaureaza nivelul scazut de L-Carnitina si metabolismul lipidic

6Acetil-L-Carnitina Acetil-L-Carnitina poate trece bariera hematoencefalica (BHE), este involvat ca mijloc de transport a L-Carnitinei

7Acetil-L-Carnitina Acetil-L-Carnitina previne pierderea celulelor nervoase

8Acetil-L-Carnitina Acetil-L-Carnitina are efect de protectie neuronala, creste significant capacitatea neuronilor periferici de supravietuire

9Acetil-L-Carnitina Acetil-L-Carnitina creste stimularea de receptorii care activeaza adenilat-ciclaza (AC) in cortexul frontal

Acetil-L-Carnitina Arginat

Acetil-L-Carnitina Arginat DHCl-dihidroclorid stimuleaza cresterea de 19,5% a neuritiilor pierduti pe masura imbatriniri, prin factorul de crestere (Nerve Growth Factor)

10Acetil-L-Carnitina Acetil-L-Carnitina cura de memorie cu suplimente nutritive cerebrale

Suplimente nutritive cerebrale

11Acid Alfa Lipoic Acetil-L-Carnitina un neuropeptid in tratamentul de Alzheimer studiu randomizat, dublu-orb, placebo controlat

Creier sanatos Creier cu Alzheimer

12Acid Alfa Lipoic Acetil-L-Carnitina in tratamentul de Alzheimer unde nu raspunde inhibitori de colinesteraza

13Acetil-L-Carnitina Acetil-L-Carnitina in tratamentul dementei usoare si mijlocii studiu randomizat, dublu-orb, placebo controlat

14Acetil-L-Carnitina Acetil-L-Carnitina in tratamentul pacientilor mai tineri de Alzheimer, studiu randomizat, dublu-orb, placebo controlat

15Acetil-L-Carnitina Acetil-L-Carnitina in tratamentul de declin mental

16Acetil-L-Carnitina Acetil-L-Carnitina creste eliberarea de dopamina de la neuroni si ajuta sa se conecteze de receptorii de dopamina

17Acetil-L-Carnitina Acetil-L-Carnitina are efect de protectie neuronala la boala Parkinson

18Acetil-L-Carnitina Acetil-L-Carnitina in comparatie cu amatadine un antiparkinsonian

19Acetil-L-Carnitina Acid Alfa Lipoic cofactor in producerea de energie in organizm, mitocondria uzina energetica decade pe masura inbatrinirii, adausul de Acetil-L-Carnitina si Acidul Alfa Lipoic prelungeste tineretea, intirzie inbatrinirea (Anti Aging), prin reducerea de stres oxidativ

Degradarea ADN/ARN prin radicalii liperi
Degradarea ADN

20Acetil-L-Carnitina Pierderea memoriei datorita mitocondria uzina energetica, care decade pe masura inbatrinirii, iar ADN/ARN se oxideaza, suplement nutritiv cu Acetil L-Carnitina si Acid alfa lipoic sau R-Acid Alfa Lipoic secretul tineretii (Anti Aging), prin reducerea de stres oxidativ

Secretul tineretii - ALCAR (Acetil-L-Carnitina) + LA (Acid Alfa Lipoic)

Secretul tineretii

21Acetil-L-Carnitina Acetil-L-Carnitina creste activitatea de translocaza in mitocondria inimii, mareste nivelul scazut de cardiolipina

22Acetil-L-Carnitina Acetil-L-Carnitina si Acid Alfa Lipoic creste functia metabolica de ATP cu reducerea de stres oxidativ

23Acetil-L-Carnitina Asociatia de Acetil-L-Carnitina cu glucoza in metabolismul musculo scheletal, efectul de hiperinsulinemia

Mentinerea diametrului muscular Atrofie musculara
Mentinerea diametrului muscular Atrofie musculara

24Acetil-L-Carnitina Acetil-L-Carnitina indicat la oboseala cronica - chronic fatigue syndrome (CFS)

25Acetil-L-Carnitina Acetil-L-Carnitina indicat la copiilor cu deficit de atentie - ADD (Attention Deficit Disorder) si copiii cu hiperactivitate - ADHD (hyperactivity disorder)

26Acetil-L-Carnitina Acetil-L-Carnitina in tratamentul durerii.

27Acetil-L-Carnitina Rolul de Acetil-L-Carnitina in neuropatologie

28Acetil-L-Carnitina Acetil-L-Carnitina in tratamentul la pacienti cu neuropatie diabetica

Dr. MD. Roy L. Waldford,
Lisa Waldford - The Anti Aging Plan
: Strategies and Recipes for Extending Your Healthy Years
Formula Anti Aging Crono Forte - Formula Anti Aging
3 Capsule contine:
Anti Aging


Acetil-L-Carnitina 1000 mg,
Carnosine 500 mg,
Acid Alfa Lipoic 150 mg,
Glutation 30 mg,
Zinc 7,5 mg,
Biotina 1500 mcg
Seleniu 50 mcg, 30 Capsule

Mod de administrare Mod de administrare:
Crono Forte 1 x 1 Capsula pe zi

 

Bibliografie-Referinte:
Bibliografie-Referinte

1. White HL, Scates PW. Acetyl-L-carnitine as a precursor of acetylcholine. Division of Pharmacology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709. Neurochem Res. 1990 Jun;15(6):597-601.
- Traina G, Valleggi S, Bernardi R, Rizzo M, Calvani M, Nicolai R, Mosconi L, Durante M, Brunelli M. Identification of differentially expressed genes induced in the rat brain by acetyl-L-carnitine as evidenced by suppression subtractive hybridisation. Dipartimento di Fisiologia e Biochimica G. Moruzzi, Universita di Pisa, Via S. Zeno, 31, 56127 Pisa, Italy. gtraina@dfb.unipi.it Brain Res Mol Brain Res. 2004 Dec 6;132(1):57-63.
2. Taglialatela G, Navarra D, Olivi A, Ramacci MT, Werrbach-Perez K, Perez-Polo JR, Angelucci L. Neurite outgrowth in PC12 cells stimulated by acetyl-L-carnitine arginine amide. Institute for Research on Senescence Sigma-Tau, Pomezia, Italy. Neurochem Res. 1995 Jan;20(1):1-9.
3. Ando S, Tadenuma T, Tanaka Y, Fukui F, Kobayashi S, Ohashi Y, Kawabata T. Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. J Neurosci Res 2001 Oct 15;66(2):266-71
4. Aureli T, Miccheli A, Ricciolini R, Di Cocco ME, Ramacci MT, Angelucci L, Ghirardi O, Conti F. Aging brain: effect of acetyl-L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy. Department of Chemistry, University of Rome La Sapienza, Italy. Brain Res. 1990 Aug 27;526(1):108-12.
5. Tanaka Y, Sasaki R, Fukui F, Waki H, Kawabata T, Okazaki M, Hasegawa K, Ando S. Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats. Neuronal Function Research Group, Division of Neuroscience and Brain Function, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. yasu@center.tmig.or.jp J Lipid Res. 2004 Apr;45(4):729-35. Epub 2004 Jan 1.
6. Inano A, Sai Y, Nikaido H, Hasimoto N, Asano M, Tsuji A, Tamai I. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan. Biopharm Drug Dispos. 2003 Nov;24(8):357-65.
7. Napoleone P, Ferrante F, Ghirardi O, Ramacci MT, Amenta F. Age-dependent nerve cell loss in the brain of Sprague-Dawley rats: effect of long term acetyl-L-carnitine treatment. Dipartimento di Scienze Neurologiche, Universita 'La Sapienza', Rome, Italy. Arch Gerontol Geriatr. 1990 Mar-Apr;10(2):173-85
8. McKay Hart A, Wiberg M, Terenghi G. Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment. Blond-McIndoe Centre, Royal Free and University College Medical School, University Department of Surgery, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK. Neurosci Lett. 2002 Dec 16;334(3):181-5.
9. Florio T, Meucci O, Grimaldi M, Ventra C, Cocozza E, Avallone A, Postiglione A, Marino A, Schettini G. Effect of acetyl-L-carnitine treatment on brain adenylate cyclase activity in young and aged rats. Dipartimento di Scienza delle Communicazioni Umane, II Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli, Italy. Eur Neuropsychopharmacol. 1993 Jun;3(2):95-101.
10. McDaniel MA, Maier SF, Einstein GO. "Brain-specific" nutrients: a memory cure? Department of Psychology, University of New Mexico, Albuquerque, New Mexico 87131, USA. mcdaniel@umn.edu Nutrition. 2003 Nov-Dec;19(11-12):957-75.
11. Bruno G, Scaccianoce S, Bonamini M, Patacchioli FR, Cesarino F, Grassini P, Sorrentino E, Angelucci L, Lenzi GL.
Acetyl-L-carnitine in Alzheimer disease: a short-term study on CSF neurotransmitters and neuropeptides. Dipartimento di Scienze Neurologiche, Universita di Roma La Sapienza, Italy. Alzheimer Dis Assoc Disord. 1995 Fall;9(3):128-31.
- Brooks JO 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Stanford University School of Medicine, California, USA. johnbrks@stanford.edu. Int Psychogeriatr. 1998 Jun;10(2):193-203.
- Rai G, Wright G, Scott L, Beston B, Rest J, Exton-Smith AN. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Department of Geriatric Medicine, Whittington Hospital, London, England. Curr Med Res Opin. 1990;11(10):638-47.
- Pettegrew JW, Klunk WE, Panchalingam K, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer’s disease. Neurobiol Aging. 1995 Jan-Feb;16(1):1-4.
- Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer’s disease. Neurology. 1991 Nov;41(11):1726-32.
- Carta A, Calvani M, Bravi D, Bhuachalla SN. Acetyl-L-carnitine and Alzheimer's disease: pharmacological considerations beyond the cholinergic sphere. Sigma-Tau Pharmaceuticals, Department of Scientific Affairs, Gaithersburg, Maryland 20878. Ann N Y Acad Sci. 1993 Sep 24;695:324-6.
12. Bianchetti A, Rozzini R, Trabucchi M. Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors. Geriatric Research Group, Brescia, Italy. angelo.bianchetti@grg-bs.it Curr Med Res Opin. 2003;19(4):350-3.
13. Passeri M, Cucinotta D, Bonati PA, Iannuccelli M, Parnetti L, Senin U. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Department of Internal Medicine, University of Parma, Italy. Int J Clin Pharmacol Res. 1990;10(1-2):75-9.
- Cucinotta D, Passeri M, Ventura S, et al. Multicenter clinical placebo-controlled study with acetyl-L-carnitine (LAC) in the treatment of mildly demented elderly patients. Drug Development Res 1988;14:213-6.
- Bonavita E. Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain. Int J Clin Pharmacol Ther Toxicol. 1986 Sep;24(9):511-6.
- Tempesta E, Casella L, Pirrongelli C, Janiri L, Calvani M, Ancona L. L-acetylcarnitine in depressed elderly subjects. A cross-over study vs placebo. Department of Psychiatry and Psychology, Catholic University of the Sacred Heart, Rome, Italy. Drugs Exp Clin Res. 1987;13(7):417-23.
- Garzya G, Corallo D, Fiore A, Lecciso G, Petrelli G, Zotti C. Evaluation of the effects of L-acetylcarnitine on senile patients suffering from depression. Multizonal Garrison Hospital V. Fazzi, Geriatric Division, Lecce, Italy. Drugs Exp Clin Res. 1990;16(2):101-6.
14. Brooks JO 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Stanford University School of Medicine, California, USA. johnbrks@stanford.edu Int Psychogeriatr. 1998 Jun;10(2):193-203.
15. Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the elderly. Institute of Gerontology and Geriatrics, Estense Hospital, University of Modena, Italy. Drugs Exp Clin Res. 1994;20(4):169-76.
16. Tolu P, Masi F, Leggio B, Scheggi S, Tagliamonte A, De Montis MG, Gambarana C. Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure. Department of Neuroscience, Pharmacology Unit, University of Siena, Siena, Italy. Neuropsychopharmacology. 2002 Sep;27(3):410-20.
- Sershen H, Harsing LG Jr, Banay-Schwartz M, Hashim A, Ramacci MT, Lajtha A. Effect of acetyl-L-carnitine on the dopaminergic system in aging brain. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962. J Neurosci Res. 1991 Nov;30(3):555-9.
- Harsing LG Jr, Sershen H, Toth E, et al. Acetyl-L-carnitine releases dopamine in rat corpus striatum: an in vivo microdialysis study. Eur J Pharmacol. 1992 Jul 21;218(1):117-21.
17. Beal MF. Bioenergetic approaches for neuroprotection in Parkinson's disease. Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA. fbeal@mail.med.cornell.edu Ann Neurol. 2003;53 Suppl 3:S39-47; discussion S47-8.
18. Tomassini V, Pozzilli C, Onesti E, Pasqualetti P, Marinelli F, Pisani A, Fieschi C. Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. Department of Neurological Sciences, University of Rome "La Sapienza", viale dell' Universita 30, Rome 00185, Italy. J Neurol Sci. 2004 Mar 15;218(1-2):103-8.
19. Hagen TM, Moreau R, Suh JH, Visioli F.Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA.Ann N Y Acad Sci. 2002 Apr;959:491-507.
- Hagen TM, Wehr CM, Ames BN. Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone.Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA. tory.hagen@orst.edu Ann N Y Acad Sci. 1998 Nov 20;854:214-23.
- Ames BN, Liu J. Delaying the mitochondrial decay of aging with acetylcarnitine. Nutritional Genomics Center, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609. bames@chori.org. Ann N Y Acad Sci. 2004 Nov;1033:108-16.
20. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA.Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2356-61.
Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1876-81
21. Paradies G, Ruggiero FM, Petrosillo G, Gadaleta MN, Quagliariello E. Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine. Department of Biochemistry and Molecular Biology, University of Bari, Italy. Mech Ageing Dev. 1995 Oct 13;84(2):103-12.
22. Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1870-5.
- Hagen TM, Ingersoll RT, Lykkesfeldt J, et al. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 1999; 13:411-418.
23. Ebeling P, Tuominen JA, Arenas J, Garcia Benayas C, Koivisto VA. The association of acetyl-L-carnitine with glucose and lipid metabolism in human muscle in vivo: the effect of hyperinsulinemia. Department of Medicine, Helsinki University Hospital, Finland. Metabolism. 1997 Dec;46(12):1454-7.
24. Vermeulen RC, Scholte HR. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Research Center Amsterdam, Amsterdam, Netherlands. info@cfscentrumamsterdam.nl. Psychosom Med. 2004 Mar-Apr;66(2):276-82.
25. Adriani W, Rea M, Baviera M, Invernizzi W, Carli M, Ghirardi O, Caprioli A, Laviola G. Acetyl-L-carnitine reduces impulsive behaviour in adolescent rats. Behavioural Neuroscience Section, Dept. Cell Biology & Neurosciences, Istituto Superiore di Sanita', viale Regina Elena 299, 00161 Rome, Italy. Psychopharmacology (Berl). 2004 Nov;176(3-4):296-304. Epub 2004 May 8.
26. Chiechio S, Copani A, Melchiorri D, Canudas AM, Storto M, Calvani M, Nicolai R, Nicoletti F. Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain. Department of Pharmaceutical Science, University of Catania, Catania, Italy. J Endocrinol Invest. 2004;27 Suppl(6):171-6.
27. Virmani A, Binienda Z. Role of carnitine esters in brain neuropathology. Scientific Affairs, Sigma-tau HealthScience, Pomezia 00040, Italy. ashraf.virmani@st-hs.it Mol Aspects Med. 2004 Oct-Dec;25(5-6):533-49.
- Sorbi S, Forleo P, Fani C, Piacentini S. Double-blind, crossover, placebo-controlled clinical trial with L-acetylcarnitine in patients with degenerative cerebellar ataxia. Department of Neurological and Psychiatric Sciences, University of Florence, Italy. Clin Neuropharmacol. 2000 Mar-Apr;23(2):114-8.
28. De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study. Department of Neuroscience, Ospedale Civile, Rovigo, Italy. ddegrandis@iol.it Drugs R D. 2002;3(4):223-31.

Literatura:

Dr. Ronald Klatz, MD. Robert Goldman - Stopping the Clock: Dramatic Breakthroughs in Anti Aging and Aging Reversal Techniques

Rita Elkins - HGH: Age Reversing Miracle

Dr. MD. Roy L Waldford - Beyond the 120 Year Diet: How to Double Your Vital Years



 
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