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  Acid Alfa Lipoic Pro  
 
Articol: Acid Alfa Lipoic Pro
Compozitie: 150 mg : Capsula
Prezentare: 1 Flacon cu 60 Capsule
Administrare: 1 -2 Capsule pe zi
Pret:
22.50
3-5 buc.: 22.05
6-8 buc.: 21.60
9-11 buc.: 21.15
12+ buc.: 20.70
 
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Acid Alfa Lipoic Pro

1Acid Alfa Lipoic Acid Alfa Lipoic, este un puternic antioxidant de 40-60 ori ca Vitamina E, cu actiune de reciclare a altor antioxidanti.

Acid Alfa Lipoic Acid Alfa Lipoic (AAL) este un di-sulfid, numit si acid tioctic sau lipoate poate regenera antioxidanti ca: Glutationul oxidat la glutation redus, Coenzima Q10, Vitamina C, Vitamina E, Glutationul disulfid, Cistina in Cisteina, Tioredoxina oxidata la Tioredoxina redusa importanta care leaga factori de transcriptie de ADN.


Acid Alfa Lipoic

Acid Alfa Lipoic Pro

Acid Alfa Lipoic

 

Acid Alfa Lipoic si Acid Dihidrolipoic (ADHL): Structura chimica
Acid Alfa Lipoic
Acid Alfa Lipoic: Formula moleculara: C8H14O2S2
Acid Alfa Lipoic: Greutatea moleculara: 206.328

Neuron Neurotransmitatorii transmit influxul nervos de la neuron spre neuriti (ramificati de dendrite si axon)
Neuron Neurotransmitatorii transmit influxul nervosAcetil-L-Carnitina

2Acid Alfa Lipoic Acetil-L-Carnitina si Acid Alfa Lipoic creste productia de ATP, rata metabolica si reduce de stresul oxidativ

- Procesul aceasta se explica prin oxidatia acidului piruvic si alfa-cetoglutaric in mitocondrie cu producerea de energie in organizm

 

Producerea de energie in organizm - Acid dihidrolipoic (ADHL)

DHLA

Mitocondria uzina energetica a materiei vii, decade pe masura inbatrinirii

Mitocondria

3Acid Alfa Lipoic Mitocondria reduce Acid Alfa Lipoic prin enzima lipoamida dehidrogenaza, in Acid Dihidrolipoic (ADHL)

Mitocondria reduce acidul alfa lipoic in Acid dihidrolipoic - Ciclul Redox
Mitocondria reduce

Acid Alfa Lipoic cu un potential de reducere a oxidatiei ORP de = -320 mV
Acid Alfa Lipoic ORP

Dihidrolipoamid dehidrogenaza catalizator si puternic antioxidant
Dihidrolipoamid dehidrogenaza catalizator

4Acid Alfa Lipoic Acid Alfa Lipoic cofactor in producerea de energie in organizm, mitocondria uzina energetica decade pe masura inbatrinirii, adausul de Acetil-L-Carnitina si Acidul Alfa Lipoic prelungeste tineretea, intirzie inbatrinirea (Anti Aging), prin reducerea de stres oxidativ

Degradarea ADN/ARN prin radicalii liperi

5Acid Alfa Lipoic Pierderea memoriei datorita mitocondria uzina energetica, care decade pe masura inbatrinirii iar ADN/ARN se oxideaza, suplement nutritiv cu Acetil L-Carnitina si Acid Alfa Lipoic secretul tineretii (Anti Aging), prin reducerea de stres oxidativ

Secretul tineretii - ALCAR (Acetil-L-Carnitina) + LA (Acid Alfa Lipoic)

Secretul tineretii

6Acetil-L-Carnitina Acid Alfa Lipoic creste circulatia in aorta, cu reoxigenarea dupa o hipoxie.

rata metabolica si reduce de stresul oxidativ

7Acid Alfa Lipoic Acid Alfa Lipoic cu efect de anti obezitate inhiba activitatea protein kinaza AMP in hipotalamus

8Ceaiul Verde In procesul de imbatrinire duplicarea ADN-ului nu se copiaza toata secventa, ci se pierde o bucatica din capatul cromozomului (Telomere), Ceaiul Verde antioxidant puternic intirzie procesul de imbatrinire, Anti Aging prin reducerea de stres oxidativ

Celula umana: Structura
Celula umana

9Cronobiologie Teoria radicalilor liberi in procesul de imbatrinire

Densitatea de neutralizare a radicalilor liberi

Celula este distrusa prin radicalii liberi:

Capacitate scazuta de neutralizare a radicalilor liberi

Antioxidanti Suficienti antioxidanti de recomandat: Acid alfa lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H 2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari

Spirulina Spirulina contine superoxid dismutaza (SOD) 110000 Unitati/100g

Capacitate suficienta de neutralizare a radicalilor liberi

Neutralizarea radicalilor liberi

Antioxidantii neutralizeaza radicali liberi
Antioxidantii

Formarea de radicali liberi
Formarea radicali liberi

Aparat de masurat capacitatea de neutralizare a radicalilor liberi
- Potential redox ORP

Potential redox ORP

10Antioxidanti Antioxidanti reduc nivelul de F-2 isoprostan, un biomarker a stresului oxidativ, neutralizeaza radicali liberi* hidroxil (OH) , radicali oxidului nitric (NO), peroxinitrit (OONO -), peroxidul de hidrogen (H2O2), oxigenul singlet (1-O2), etc.

Actiunea Acidului Alfa Lipoic

11Acid Alfa Lipoic Actiunea de regenerare a acidului alfa lipoic si a altor antioxidanti Vitamina C (acidul dehidroascorbic forma oxidata) etc.

12Acid Alfa Lipoic Mitocondria reduce Acid Alfa Lipoic prin enzima lipoamida dehidrogenaza in Acid Dihidrolipoic (ADHL)

Mitocondria reduce Acid Alfa Lipoic prin enzima lipoamida dehidrogenaza in Acid Dihidrolipoic (ADHL)
R-Acid Alfa Lipoic

13Acid Alfa Lipoic Acid Alfa Lipoic previne oxidarea de LDL colesterol implicat in bolile de inima la ateroscleroza

14Acid Alfa Lipoic Acid Alfa Lipoic reduce rectiile de glicozilare in diabetul zaharat tip 2

15Acid Alfa Lipoic Efectul benefic al acidului alfa lipoic si Vitamina C la pacienti cu diabetul zaharat tip 2

16Acid Alfa Lipoic Acid Alfa Lipoic indicat in tratamentul de neuropatie diabetica-polineuropatie diabetica, studiu randomizat, dublu-orb, placebo controlat.

17Acid Alfa Lipoic Acid Alfa Lipoic creste numarul de anticorpi este imunomodulator

18Acid Alfa Lipoic Acid Alfa Lipoic cu actiunea sa antioxidanta previne, ajuta la bolile ochilor

19Acid Alfa Lipoic Acid Alfa-Lipoic este un Anti Aging are actiune neuroprotectiva previne bolile degenerative, intirzie inbatrinirea

Dr. MD. Roy L. Waldford,
Lisa Waldford - The Anti Aging Plan
:
Strategies and Recipes for Extending
Your Healthy Years
Formula Anti Aging Crono Forte - Formula Anti Aging
3 Capsule contine:
Anti Aging Systeme


Acetil-L-Carnitina 1000 mg,
Carnosine 500 mg,
Acid Alfa Lipoic 150 mg,
Glutation 30 mg,
Zinc 7,5 mg,
Biotina 1500 mcg
Seleniu 50 mcg, 30 Capsule

Mod de administrare Mod de administrare:
Crono Forte 1 x 1 Capsula pe zi

 

Bibliografie-Referinte:
Bibliografie-Referinte

1.Packer L, Witt EH, Tritschler, HJ. Alpha-lipoic as a biological antioxidant. Free Rad Biol Med. 1995; 19:227-250.
- Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age-associated decline in ascorbic and concentration, recycling and biosynthesis in rat hepatocytes-reversal with (R)-alpha-lipoic acid supplementation. FASEB J. 1998; 12:1183-1189.
2. Reed LJ. The chemistry and function of lipoic acids. Adv Enzymol. 1957; 18:319-347.
- Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1870-5.
- Hagen TM, Ingersoll RT, Lykkesfeldt J, et al. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 1999; 13:411-418.

3. The pharmacology of the antioxidant lipoic acid. Biewenga GP, Haenen GR, Bast A. Gen Pharmacol. 1997 Sep;29(3):315-31. 1.
4. Hagen TM, Moreau R, et al: Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-l-carnitine and/or lipoic acid. Ann N Y Acad Sci 2002 Apr;959:491-507
- Hagen T, Wehr C, Ames B. Mitochondrial decay in aging-Reversal through supplementation of Acetyl-L-Carnitine and N-tert-Butyl-alpha-phenyl-nitrone. Ann N Y Acad Sci. 1998 Nov 20;854:214-23.
5. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2356-61.
- Ames BN, Liu J. Delaying the mitochondrial decay of aging with acetylcarnitine. Nutritional Genomics Center, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609. bames@chori.org. Ann N Y Acad Sci. 2004 Nov;1033:108-16.
- Paradies G, Ruggiero FM, Petrosillo G, et al. Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine. Mech Ageing Dev. 1995 Oct 13;84(2):103-12.
6. Zimmer G, Beikler TK, Schneider M, et al. Dose/response curves of lipoic acid R- and S- forms in the working rat heart during reoxygenation: superiority of the R-entantiomer in the enhancement of aortic flow. J Mol Cell Cardiol. 1995; 27:1895-1903.
7. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KU. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Department of Internal Medicine, University of Ulsan College of Medicine, 138-736 Poongnap-dong, Songpa-ku, Seoul 138-736, Korea.
8. Boukamp P. Ageing mechansisms: the role of telomere loss. Clin Exp Dermatol, 2001; 26: 562-5.
- Lorenz M, Saretzki, Sitte N, Metzkow S, Von Zglinicki T. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Rad Biol Med, 2001; 31: 824-31.
- H. Ochi. Rouka seigyo syokuhin no kaihatsu (Development of foods for control of aging) Korin Press, p. 294, 1995.
9. Beckman, K. & Ames, B. (1998) "The free radical theory of aging matures" Physiol Rev 78: 548-81.
10. Dietrich, M., G. Block, M. Hudes, J. D. Morrow, E. P. Norkus, M. G. Traber, C. E. Cross and L. Packer (2002). "Antioxidant supplementation decreases lipid peroxidation biomarker F(2)- isoprostanes in plasma of smokers." Cancer Epidemiol Biomarkers Prev 11(1): 7-13.
- Calabrese V, Ravagna A, Colombrita C, Scapagnini G, Guagliano E, Calvani M, Butterfield DA, Giuffrida Stella AM. Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2. Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. J Neurosci Res. 2005 Jan 7.
- Marangon K, Devaraj S, Tirosh O, et al. Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress. Free Rad Biol Med. 1999; 27:1114-1121.
- Kagan V, Khan S, Swanson C, et al. Antioxidant action of thioctic acid and dihydrolipoic acid. Free Radic Biol Med 1990;9S:15.
- Martin E, Rosenthal RE, Fiskum G. Pyruvate dehydrogenase complex: Metabolic link to ischemic brain injury and target of oxidative stress. Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland. J Neurosci Res. 2005 Jan 1;79(1-2):240-7.
11. Scholich H, Murphy ME, Sies H. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol. Biochem Biophys Acta 1989;1001:256–61.
- Kagan V, Serbinova E, Packer L. Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem Biophys Res Commun 1990;169:851–7.
- Busse E, Zimmer G, Schorpohl B, et al. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittelforschung1992;42:829–31.
12. Reduction of lipoic acid by lipoamide dehydrogenase. Biewenga GP, Dorstijn MA, et al. Biochem Pharmacol. 1996 Feb 9;51(3):233-8.
13. Nichols TW Jr. Alpha-lipoic acid: biological effects and clinical implications. Altern Med Rev 1997;2:177–83
14. Jacob S, Henriksen EJ, Schiemann AL, Simon I, Clancy DE, Tritschler HJ, Jung WI, Augustin HJ, Dietze GJ. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Department of Internal Medicine, City Hospital, Baden-Baden, Germany. Arzneimittelforschung. 1995 Aug;45(8):872-4.
- Wagh SS, Natraj CV, Menon KKG. Mode of action of lipoic acid in diabetes. J Biosci. 1987; 11:59-74.
- Jacob S Streeper RS Fogt DL Hokama JY Tritschler HJ Dietze GJ Henriksen EJ, The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes. 1996 Aug; 45(8): 1024-9 1996 0012-1797.
- Natrej CV, Gandhi VM, Melon KKG. Lipoic acid and diabetes: effect of dihydrolipoic acid administration in diabetic rats and rabbits. J Biosci 1984; 6:37-46.
15. Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A, Meinertz T. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Universitatsklinikum Hamburg-Eppendorf Klinik und Poliklinik fur Innere Medizin, Abteilung Kardiologie, Hamburg, Germany. heitzer@uke.uni-hamburg.de. Free Radic Biol Med. 2001 Jul 1;31(1):53-61.
16. Nickander KK, McPhee BR, Low PA, Tritschler H. Alpha-lipoic acid: antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy. Free Rad Biol Med. 1996; 21:631-639.
- Sachse G, Willms B. Efficacy of throctic acid in the therapy of peripheral diabetic neuropathy. Horm Metab Res Suppl. 1980; 9:105-107.
Studiu randomizat, dublu-orb, placebo controlat
-
Sima AA, Calvani M, Mehra M, Amato A. Acetyl-L-Carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy: An analysis of two randomized placebo-controlled trials. Department of Pathology, Wayne State University School of Medicine, 540 E. Canfield Ave., Detroit, MI 48201. asima@med.wayne.edu. Diabetes Care. 2005 Jan;28(1):89-94.
- Ziegler D, Hanefeld M, Ruhnau KJ, Meissner HP, Lobisch M, Schutte K, Gries FA. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetes-Forschungsinstitut an der Heinrich-Heine-Universitat, Dusseldorf, Germany. Diabetologia. 1995 Dec;38(12):1425-33.
- Ziegler, D., H. Schatz, F. Conrad, F. A. Gries, H. Ulrich and G. Reichel (1997). "Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie." Diabetes Care 20(3): 369-73.
- Ziegler D, Hanefeld M, Ruhnau KJ, Hasche H, Lobisch M, Schutte K, Kerum G, Malessa R. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). Diabetes-Forschungsinstitut an der Heinrich-Heine-Universitat, Dusseldorf, Germany. dan.ziegler@dfi.uni-duesseldorf.de. Diabetes Care. 1999 Aug;22(8):1296-301.
- Ziegler, D. and F. A. Gries (1997). "Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy." Diabetes 46 Suppl 2: S62-6.
- Ruhnau, K. J., H. P. Meissner, J. R. Finn, M. Reljanovic, M. Lobisch, K. Schutte, D. Nehrdich, H. J. Tritschler, H. Mehnert and D. Ziegler (1999). "Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy." Diabet Med 16(12): 1040-3.
- Reljanovic M, Reichel G, Rett K, Lobisch M, Schuette K, Moller W, Tritschler HJ, Mehnert H. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). University of Clinic for Diabetes, Endocrinology and Metabolic Diseases Vuk Vrhovac, Medical faculty, University of Zagreb, Coratia. Free Radic Res. 1999 Sep;31(3):171-9.
17. Ohmori H, Yamauchi T, Yamamoto I. Augmentation of the antibody response by lipoic acid in mice II. Restoration of the antibody response in immunosuppressed mice. Japan J Pharmacol 1986; 42:275-280.
18. Filina AA, Davydova NG, Endrikhovskii SN, Shamshinova AM. Lipoic acid as a means of metabolic therapy of open-angle glaucoma. Vestn Oftalmol. 1995 Oct-Dec;111(4):6-8.
19. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Rad Biol Med. 1997; 22:359-378.
- Tirosh O, Sen CK, Roy S, et al. Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue. Free Rad Biol Med. 1999; 26:1418-1426.

Literatura

- Packer L, Colman C: The Antioxidant Miracle. John Wiley & Sons, New York 1999.



 
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