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  Carnosine  
 
Articol: Carnosine
Compozitie: 80 mg: Capsula
Prezentare: 1 Flacon cu 30 Capsule
Administrare: 1 - 2 Capsule pe zi
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Carnosine

1Carnosine Carnosine cu protectie Anti Aging, Carnosine este o legatura chimica organica intre aminoacizii: L-Alanina si L-Histidina (dipeptizi)

Carnosine Legatura intre trei aminoacizi se numeste tripeptizi, mai mult ca zece aminoacizi se numeste polipeptizi

2CarnosineCarnosine creste vitalitatea, prelungeste tineretea, intirzie imbatrinirea Anti Aging reduce accelerarea senescentei


Carnosine

Carnosine

Carnosine

 

3Carnosine Carnosine cu proprietati fiziologice si potential terapeutic

Terapia Anti Aging cu Carnosine
Carnosine cu efect de longevitate (Life Extension)
Terapia Anti Aging

Carnosine (beta-Alanyl-L-Histidine): Structura chimica
Carnosine
Carnosine: Formula moleculara: C9H14N4O3
Carnosine: Greutatea moleculara: 226.23

4Carnosine Carnosine previne atrofia musculara de pina la 50% in bolile sistemului neuromuscular si cel musculo-scheletal, cantitatea de Carnosine scade in tesutul muscular cu 63% intre 10-70 de ani

Carnosine previne atrofia musculara

 

Mentinerea diametrului muscular Atrofie musculara
Mentinerea diametrului muscular Atrofie musculara

5Carnosine Concentratia inalta de Carnosine cu efect in tesutul muscular la sprintul maximal pe ergometru timp de 30 secunde

6Carnosine Efectul de Carnosine si zinc chelat in functia musculara

7Carnosine Carnosine cu protectie a fibrelor musculare de oboseala

8Carnosine Carnosine un Anti Aging antioxidant previne degradarea proteica (proteoliza), reactii de carbonilare grupa de carbonil (> C=O) se leaga de moleculele de proteina, rezulta oxidarea proteica

Grupa de carbonil
Grupa de carbonil

9Carnosine Carnosine reduce degradarea proteica (proteoliza) prin peroxidarea lipidica cauza degradarii proteice, reduce reactiile de glicozilare (AGEs) de incrucisare (crosslinked) cu glucoza si cu efect protectiv in rectiile de malonilare

- Glicozilare sint reactii necontrolate ne-enzimatice ale glucozei cu proteinele

Carnosine inhiba reactiile de glicozilare (AGEs), de brunificare si reducere a eslasticitatii tesutului de colagen in procesul de inbatrinire
glicozilare- brunificare

10Carnosine Carnosine cu rol de inhibare a reactiilor de glicozilare (AGEs), de brunificare si reducere a eslasticitatii tesutului de colagen in procesul de inbatrinire

11Carnosine Carnosine cu efect in tratamentul dupa accidentul vascular cerebral

Accident vascular cerebral
Accident vascular cerebral

12Carnosine Carnosine cu efect in tratamentul atac ischemic tranzitor

13Carnosine Carnosine (beta-alanyl-L-histidine) un natural antioxidant care neutralizeaza radicalii liberi hidroxil (OH), oxigenul singlet (1-O2) si inhiba peroxidarea lipidica

Celula umana: Structura
Celula umana

14Cronobiologie Teoria radicalilor liberi in procesul de imbatrinire

Densitatea de neutralizare a radicalilor liberi

Celula este distrusa prin radicalii liberi:

Capacitate scazuta de neutralizare a radicalilor liberi

neutralizarea radicalilor liberi

Antioxidantii neutralizeaza radicali liberi
Antioxidantii

Formarea de radicali liberi
Formarea radicali liberi

15Carnosine Carnosine antioxidant cu efect protectiv de moartea celulara cauzata de radicalii liberi

16Carnosine Suficienti antioxidanti de recomandat: Carnosine, Acid alfa lipoic, Ceai Verde, Coenzima Q10, Vitamina C, Glutation, Vitamin E, Carotenoizi sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari

Capacitate suficienta de neutralizare a radicalilor liberi

Neutralizarea radicalilor liberi

Aparat de masurat capacitatea de neutralizare a radicalilor liberi
- Potential redox ORP

Potential redox ORP

17Carnosine Teoria redox si neuro chimia, ca baza la invatat-neurocibernetica

18Carnosine N-Acetil Carnosine un antioxidant de uz oftalmic in tratamentul cataractei

19Carnosine Adausul de Carnosine la copii cu autism, studiu randomizat, dublu-orb, placebo controlat

20Carnosine Carnosine cu potential in terapia de scleroza amiotrofica laterala

21Carnosine Carnosine in mecanismul endogen de neuroprotectie, un Age inhibitor indicat la dementa.

Suplimente nutritive cerebrale

22Carnosine Carnosine cu efect de protectie a placilor de beta-amiloid in boala Alzheimer

Creier sanatos Creier cu Alzheimer

23Carnosine Carnosine cu actiune de vindecare a ranilor

24Carnosine Carnosine un modulator intracelular al calciului in contractia celulei cardiace

25Carnosine Carnosine cu efect in bolile cardovascular

26Carnosine Carnosine are efect de inhibare a oxidarii lipoproteinelor cu densitate joasa

27Carnosine Carnosine cu actiune de vasodilatare

Dr. MD. Roy L. Waldford,
Lisa Waldford - The Anti Aging Plan
:
Strategies and Recipes for Extending
Your Healthy Years
Formula Anti Aging Crono Forte - Formula Anti Aging
3 Capsule contine:
Anti Aging Systeme


Acetil-L-Carnitina 1000 mg,
Carnosine 500 mg,
Acid Alfa Lipoic 150 mg,
Glutation 30 mg,
Zinc 7,5 mg,
Biotina 1500 mcg
Seleniu 50 mcg, 30 Capsule

Mod de administrare Mod de administrare:
Crono Forte 1 x 1 Capsula pe zi

 

Bibliografie-Referinte:
Bibliografie-Referinte

1. Boldyrev AA, Gallant SC, Sukhich GT Carnosine, the protective, anti-aging peptide. Center for Molecular Medicine, Department of Biochemistry, Biological Faculty, MV Lomonosov, Moscow State University, Vorobjovy Gory, Russia. aab@1.biocenter.bio.msu.ru Biosci Rep 1999 Dec;19(6):581-7
- Hipkiss AR Carnosine, a protective, anti-ageing peptide? Molecular Biology and Biophysics Group, King's College London, Strand, UK. Int J Biochem Cell Biol 1998 Aug;30(8):863-8
- Hipkiss AR, Brownson C. A possible new role for the anti-ageing peptide carnosine. Biomolecular Sciences Division, GKT School of Biomedical Sciences, King's College London, UK. alan.hipkiss@kcl.ac.uk Cell Mol Life Sci. 2000 May;57(5):747-53.
- Hipkiss AR, Preston JE, Himsworth DT, et al. Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann NY Acad Sci. 1998; 854:37-53.
2. McFarland GA, Holliday R. Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts. Exp Gerontol. 1999; 34(1):35-45.
- Hipkiss AR, Michaelis J, Syrris P, et al. Strategies for the extension of human life span. Perspect Hum Biol. 1995; 1:59-70.
- McFarland GA, Holliday R. Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res 1994; 212(2):167-75.
- McFarland GA, Holliday R. Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts. Exp Gerontol. 1999; 34(1):35-45.
- Yuneva MO, Bulygina ER, Gallant SC, et al. Effect of carnosine on age-induced changes in senescence-accelerated mice. J Anti-Aging Med. 1999; 2(4):337-42.
- Wang AM, Ma C, Xie ZH, et al. Use of carnosine as a natural anti-senescence drug for human beings. Biochemistry (Moscow). 2000; 65(7):869-71.
3. Gariballa SE, Sinclair AJ. Carnosine: physiological properties and therapeutic potential. Sheffield Institute of Studies on Ageing, The University of Sheffield, Barnsley General Hospital, UK. Age Ageing. 2000 May;29(3):207-10.
4. Stuerenburg HJ. The roles of carnosine in aging of skeletal muscle and in neuromuscular diseases. Biochemistry (Mosc). 2000 Jul;65(7):862-5.
5. Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K. High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting. Doctoral Program in Health and Sport Sciences, University of Tsukuba, Japan. Jpn J Physiol. 2002 Apr;52(2):199-205.
6. Tameyasu T, Yamada M, Tanaka M, Takahashi S. Effect of zinc-carnosine chelate compound on muscle function in mdx mouse. Department of Physiology, St. Marianna University School of Medicine, Kawasaki, 216-8511 Japan. t2tame@marianna-u.ac.jp. Jpn J Physiol. 2002 Feb;52(1):111-20.
7. Rubtsov AM. Molecular mechanisms of regulation of the activity of sarcoplasmic reticulum Ca-release channels (ryanodine receptors), muscle fatigue, and Severin's phenomenon. Department of Biochemistry, School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia. am_rubtsov@mail.ru. Biochemistry (Mosc). 2001 Oct;66(10):1132-43.
8. Hipkiss AR, Brownson C, Carrier MJ. Carnosine, the ANTI-AGEING, anti-oxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev 2001, 122(13):1431-45
- Hipkiss AR, Brownson C. Carnosine reacts with protein carbonyl groups: another possible role for the ANTI-AGEING peptide? Biogerontology 2000, 1(3):217-23
- Stadtman ER. Protein oxidation and aging. Science. 1992; 257(5074):1220-4.
- Stadtman ER, Levine RL. Protein oxidation. Ann NY Acad Sci. 2000; 899:191-208.
- Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem. 1997; 272(33):20313-6.
9. Burcham PC, Kuhan YT. Diminished susceptibility to proteolysis after protein modification by the lipid peroxidation product malondialdehyde: inhibitory role for crosslinked and noncrosslinked adducted proteins. Arch Biochem Biophys. 1997; 340(2):331-7.
- Brownson C, Hipkiss AR. Carnosine reacts with a glycated protein. Free Radic Biol Med. 2000; 28(10):1564-70.
- Hipkiss AR, Michaelis J, Syrris P. Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett. 1995; 371(1):81-5.
- Hipkiss AR, Preston JE, Himswoth DT, et al. Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells. Neurosci Lett. 1997; 238(3):135-8.
- Bierhaus A, Hofmann MA, Ziegler R, et al. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept. Cardiovascular Research. 1998; 37(3):586-600.
10. Thorpe SR, Baynes JW. Role of the Maillard reaction in diabetes mellitus and diseases of aging. Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, USA. Drugs Aging. 1996 Aug;9(2):69-77.
- David L. Price, Patricia M. Rhett, Suzanne R. Thorpe, and John W. BaynesDagger. Chelating Activity of Advanced Glycation End-product Inhibitors. From the Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208. J. Biol. Chem., Vol. 276, Issue 52, 48967-48972, December 28, 2001
11. Gallant S, Kukley M, Stvolinsky S, Bulygina E, Boldyrev A. Effect of carnosine on rats under experimental brain ischemia. Zoetic Neurosciences Ltd., England, UK. Tohoku J Exp Med. 2000 Jun;191(2):85-99.
12. Stvolinsky SL, Dobrota D.Anti-ischemic activity of carnosine. Laboratory of Clinical Neurochemistry, Institute of Neurology, Russian Academy of Medical Sciences, Moscow, 123367 Russia. sls@bio.inevro.msk.ru. Biochemistry (Mosc). 2000 Jul;65(7):849-55.
- Suslina ZA, Federova TN, Maksimova MIu, Riasina TV, Stvolinskii SL, Khrapova EV, Boldyrev AA. Antioxidant therapy in ischemic stroke Zh Nevrol Psikhiatr Im S S Korsakova. 2000;100(10):34-8.
13. Babizhayev MA, Seguin MC, Gueyne J, Evstigneeva RP, Ageyeva EA, Zheltukhina GA. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. Moscow Helmholtz Research Institute of Eye Diseases, Russia. Biochem J. 1994 Dec 1;304 ( Pt 2):509-16.
- Decker EA, Livisay SA, Zhou S. A re-evaluation of the antioxidant activity of purified carnosine. Department of Food Science, Chenoweth Lab, University of Massachusetts, Amherst, MA 01003, USA. edecker@foodsci.umass.edu. Biochemistry (Mosc). 2000 Jul;65(7):766-70.
- Chan WK, Decker EA, Chow CK, Boissonneault GA. Effect of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid oxidation in rat skeletal muscle. Department of Animal Sciences, University of Massachusetts, Amherst 01003. Lipids. 1994 Jul;29(7):461-6.
- Hartman PE, Hartman Z, Ault KT. Scavenging of singlet molecular oxygen by imidazole compounds: high and sustained activities of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic acid. Department of Biology, Johns Hopkins University, Baltimore, MD 21218. Photochem Photobiol. 1990 Jan;51(1):59-66.
- Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Kondo M. The antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-L-histidinato zinc. First Department of Medicine, Kyoto Prefectural University of Medicine, Japan. Biochim Biophys Acta. 1991 Nov 14;1115(1):15-22.
- Gulyaeva NV, Dupin AM, Levshina IP. Carnosine prevents activation of free-radical lipid oxidation during stress. Bull Exp Biol Med. 1989; 107(2):148-152.
- Gulyaeva NV. Superoxide-scavenging activity of carnosine in the presence of copper and zinc ions. Biochemistry (Moscow). 1987; 52(7 Part 2):1051-4.
14. Beckman, K. & Ames, B. (1998) "The free radical theory of aging matures" Physiol Rev 78: 548-81.
15. Boldyrev A, Song R, Lawrence D, et al. Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species. Neuroscience. 1999; 94(2):571-7.
- MacFarlane N, McMurray J, O'Dowd JJ, Dargie HJ, Miller DJ. Synergism of histidyl dipeptides as antioxidants. Institute of Physiology, Glasgow University, UK. J Mol Cell Cardiol. 1991 Nov;23(11):1205-7.
16. Chan WK, Decker EA, Chow CK, Boissonneault GA. Effect of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid oxidation in rat skeletal muscle. Department of Animal Sciences, University of Massachusetts, Amherst 01003. Lipids. 1994 Jul;29(7):461-6.
- Kang JH, Kim KS, Choi SY, Kwon HY, Won MH, Kang TC. Protection by carnosine-related dipeptides against hydrogen peroxide-mediated ceruloplasmin modification. Department of Genetic Engineering, Chongju University, Korea. jhkang@chongju.ac.kr. Mol Cells. 2002 Feb 28;13(1):107-12.
17. Smythies J. The neurochemical basis of learning and neurocomputation: the redox theory. Department of Neuropsychiatry Institute of Neurology London UK. smythies@psy.ucsd.edu Behav Brain Res (1999 Feb 15) 99(1):1-6
- Smythies J. Redox mechanisms at the glutamate synapse and their significance: a review. Institute of Neurology, London, UK. smythies@psy.ucsd.edu. Eur J Pharmacol. 1999 Apr 1;370(1):1-7.
18. Babizhayev MA, Yermakova VN, Semiletov YA, Deyev AI. The natural histidine-containing dipeptide Nalpha-acetylcarnosine as an antioxidant for ophthalmic use. Innovative Vision Products Inc., County of New Castle, Delaware 19810, USA. (Mosc). 2000 May;65(5):588-98.
- Babizhayev MA, Yermakova VN, Sakina NL, Evstigneeva RP, Rozhkova EA, Zheltukhina GA. N alpha-acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as antioxidant. Moscow Helmholtz Research Institute of Eye Diseases, Russian Federation. Clin Chim Acta. 1996 Oct 15;254(1):1-21.
- Babizhayev MA, Deyev AI, Yermakova VN, Semiletov YA, Davydova NG, Kurysheva NI, Zhukotskii AV, Goldman IM. N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts. Innovative Vision Products, Inc., County of New Castle, DE 19810, USA. markbabizhayev@mail.ru Peptides. 2001 Jun;22(6):979-94.
- Babizhayev MA, Deyev AI, Yermakova VN, Brikman IV, Bours J. Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes. Innovative Vision Products Inc., County of New Castle, Delaware, USA. marlbabizhayev2004@yahoo.com Drugs R D. 2004;5(3):125-39.
19. Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, Komen J. Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders. Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL 60044, USA. mchezmd@interaccess.com J Child Neurol. 2002 Nov;17(11):833-7.
20. Kang JH, Eum WS. Enhanced oxidative damage by the familial amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutants. Biochim Biophys Acta. 2000 Dec 15;1524(2-3):162-70.
21. Horning MS, Blakemore LJ, Trombley PQ. Endogenous mechanisms of neuroprotection: role of zinc, copper, and carnosine. Brain Res. 2000; 852(1):56-61.
- Stvolinsky SL, Kukley ML, Dobrota D, et al. Carnosine: an endogenous neuroprotector in the ischemic brain. Cell Mol Neurobiol. 1999; 19(1):45-56.
- Boldyrev AA, Stvolinsky SL, Tyulina OV, et al. Biochemical and physiological evidence that carnosine is an endogenous neuroprotector against free radicals. Cell Mol Neurobiol. 1997; 17(2):259-71.
- Dukic-Stefanovic S, Schinzel R, Riederer P, Munch G. AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? Physiological Chemistry I, Biocenter, University of Wurzburg, Germany. Biogerontology. 2001;2(1):19-34.
22. Preston JE, Hipkiss AR, Himsworth DT, et al. Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine. Neurosci Lett. 1998; 242(2):105-8.
- Munch G, Mayer S, Michaelis J, et al. Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide. Biochim Biophys Acta. 1997; 1360(1):17-29.
- Munch G, Schinzel R, Loske C, et al. Alzheimer's disease-synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. Journal of Neural Transmission. 1998; 105(4-5):439-61.
23. Nagai K, Suda T, Kawasaki K, et al. Action of carnosine and beta-alanine on wound healing. Surgery. 1986; 100(5):815-21.
24. Zaloga GP, Roberts PR, Black KW, Lin M, Zapata-Sudo G, Sudo RT, Nelson TE. Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells. Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA. Am J Physiol. 1997 Jan;272(1 Pt 2):H462-8.
25. Roberts PR, Zaloga GP. Cardiovascular effects of carnosine. Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1009, USA. Biochemistry (Mosc). 2000 Jul;65(7):856-61.
26. Decker EA, Ivanov V, Zhu BZ, Frei B. Inhibition of low-density lipoprotein oxidation by carnosine histidine. Department of Food Science, Chenoweth Laboratory, University of Massachusetts, Amherst 01003, USA. edecker@foodsci.umass.edu. J Agric Food Chem. 2001 Jan;49(1):511-6.
27. Ririe DG, Roberts PR, Shouse MN, Zaloga GP. Vasodilatory actions of the dietary peptide carnosine. Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1009, USA. dririe@bgsm.edu. Nutrition. 2000 Mar;16(3):168-72.

Literatura

"Carnosine and other Elixirs of Youth - The Miraculous Anti-Ageing Supplement" - by Marios Kyriazis



 
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