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  Coenzima Q10  
 
Articol: Coenzima Q10
Compozitie: Q10-30 mg: Capsula
Prezentare: 1 Flacon cu 30 Capsule
Administrare: 1 Capsula pe zi
Pret:
325000.00
3-5 buc.: 318500.00
6-8 buc.: 312000.00
9-11 buc.: 305500.00
12+ buc.: 299000.00
 
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Coenzima Q10 (Ubiquinona, CoQ10)

1Coenzima Q10 Coenzima Q10 previne imbatranirea prematura (Anti Aging), studiile internationale au demonstrat ca nivelul redus de Coenzima CoQ10 contribuie in mod direct la imbatranire.

Coenzima Q10 Coenzima Q10 participa la foarte multe reactii enzimatice, in celulele organismului Coenzima Q10 este utilizata in procesul de respiratie.

Coenzima Q10

Coenzima Q10

Coenzima Q10

- Coenzima Q10 a fost descoperita in anul 1957.
-1978 a primit Dr.Mitchell P. Premiul nobel, pentru importanta Coenzimei Q10.

Coenzima Q10: Structura chimica
Coenzima Q10: Formula moleculara: C59H90O4
Coenzima Q10: Greutatea moleculara: 863.36

Ubi = (lat.) Peste tot
Quinona = Structura biochimica a Coenzimei Q10.

- Sinteza de Coenzimei Q10 se produce din Aminoacizii: L-Phenilalanina, L-Tirozina, si L-Metionina, cu participarea de Vitamina B12, Acid Folic si Vitamina B Complex..

https://bioveliss-tabs.com/

Concentratia de Coenzima Q10 in mitocondrie

Concentratia de Coenzima Q10 In Mitocondrie

2Coenzima Q10 Coenzima Q10 se gaseste in mitocondrii: Mitocondria uzina energetica de adenozintrifosfat (ATP) a materiei vii, activeaza energia corporala de adenozintrifosfat (ATP)

Adenozintrifosfat ATP

3Coenzima Q10 Coenzima Q10 previne oboseala si stresul, Coenzima Q10 un produs ideal cu biodisponibilitate biologica.

4Coenzima Q10 Coenzima Q10 ca antioxidant in mitocondrii si celule cu protectia de peroxidare lipidica, CoQ10 reduce oxidarea si leziunea ADN in limfocite

Densitatea de neutralizare a radicalilor liberi

Celula este distrusa prin radicalii liberi:

Capacitate scazuta de neutralizare a radicalilor liberi

Suficienti antioxidanti: Acid alfa lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari

Spirulina alge contine superoxid dismutaza (SOD) 110000 Unitati/100g

Capacitate suficienta de neutralizare a radicalilor liberi

Neutralizarea radicalilor liberi

Aparat de masurat capacitatea de neutralizare a radicalilor liberi
- Potential redox ORP

Potential redox ORP

- Coenzima Q10 este o substanta vitala, un antioxidant puternic, neutralizeza radicalii liberi, ajuta la preintampinarea efectelor toxice exercitate de multe medicamente sintetice

Coenzima Q10 stabilizeaza membrana celulara.

Coenzima Q10 Membrana Celulara

- Coenzima Q10 ca stabilizator in membrana celulara asigura permeabilitatea membranei celulare pentru ca substantele vitale sa poata intra in celula.
Pentru a asigura aceasta functie Coenzima Q10 este depozitata in membrana celulara
- Coenzima Q10 are concentratii diferite in organe
- Concentratia cea mai mare de Coenzima Q10 se gaseste in inima, ficat si in organele cu necesar mare de energie.

Concentratia de Coenzima Q10 in diferite alimente

Coenzima Q10 Alimente

- Concentratia cea mai mare de Coenzima Q9 se gaseste in Chlorella cu 14mg /100g care este transformata in ficat in Coenzima Q10.

 Coenzima Q10 Anti Aging

- Scaderea concentratiei de Coenzima Q10, pe masura imbatranirii

Organul La virsta de 39-42 ani % Q10 La virsta de 77-81 ani % Q10
Inima
-31,8
-57,1
Plamin
+/- 0
-48,3
Splina
-12,8
-60,1
Ficat
-4,7
-17,2
Rinichi
-27,4
-34,7
Pancreas
-8,7
-69,0
Glanda Suprarenala
-24,2
-47,2

- Coenzima Q10 reduce riscul de aparitie a bolilor cardiovasculare prin imbunatatirea oxigenarii miocardului cu 20% (rol deosebit de important bolnavilor cu infarct miocardic, insuficienta miocardica hipertensiune arteriala)

https://www.vicodur.com/vivese-senso-duo/

5Coenzima Q10 Deficienta de Coenzima Q10 la boli de inima, ca adjuvant in terapia infarctului miocardic

6Coenzima Q10 Coenzima Q10 reduce frecventa la boli de cancer

7Coenzima Q10 Coenzima Q10 are un impact important in eficienta controlului glicemic a pacientilor cu diabet zaharat tip 1

8Coenzima Q10 Coenzima Q10 este imunostimulator previne imunodeficienta (HIV)

9Coenzima Q10 Coenzima Q10 previne dezvoltarea paradontozei si gingivita

10Coenzima Q10 Coenzima Q10 ajuta la preintampinarea efectelor toxice exercitate de multe medicamente sintetice

11Coenzima Q10 Coenzima Q10 cu efect pozitiv in terapia de cardiopatie coronariana,

Cardiopatia ischemica poate fi produsa de cauze organice cum ar fi:
Leziuni in peretii vasculari datorita oxidatiei din insuficienta a antioxidantilor pentru reducerea radicalilor liberi, Coenzima Q10 este un antioxidant puternic.

- De ce nu primesc animalele infarct miocardic (Dr.Rath), pentru ca animalele produc ele insesi Vitamina C

12Coenzima Q10 Vitaminei C ca antioxidant reduce colesterolul foarte important in bolile cardiovasculare

13Vitamina C Vitaminei C inhiba oxidatia lipoproteinelor cu densitate mica LDL - colesterol

- Din lipsa cronica de Vitamina C peretii vasculari primesc leziuni iar efectele de reparatie a organizmului compenseaza necontrolat cresterea cu celule musculare
Depunerilor cu Lipoproteina(a) = apoa in placa aterosclerotica; Liproproteina(a) are efect de lipire (Adeziune) de peretii vasculari, a moleculei LDL (Low Density Lipoprotein) a depunerilor de molecule de Calciu si molecule de Zahar (glucoza).

14Vitamina C Coenzima Q10 inhiba oxidatia lipoproteinelor cu densitate mica LDL - colesterol, oxidatia LDL-colesterol poarta un rol esential in patogenia aterosclerozei

- Stabilizarea peretilor vasculari cu adaos de Vitamina C, L-Lizina, L-Prolina, Condroitinsulfat important pentru producerea de colagen, elastina, suplimentar asigura producerea unui film protector de tip (Teflon), prin L-Lizina si L-Prolina (Aminoacizi).

- Alte efecte secundare sint cresterea nivelul de colesterol, scaderea tigliceridelor indicat, adaosul de Vitamina C (Ginter, Haarwood), Vitamina B3 (Altschul, Carlson, Guraker, Levie), B5 (Avogaro, Cherechi, Gadie, Beamish), B6, B12, Vitamina E, L-Carnitina (Opie)

Tensiunea arterialala (Hipertonie) persoanele fara tensiune posed in arterii o vasodilatatie (Relaxing) normala.
- Pentru scaderea tensiunii arteriale studiile stiintifice recomanda adaosul de Coenzima Q10 (Digiesi), Magneziu (Turlapaty, Widman), L-Arginina (Korbut) influenteaza favorabil scaderea tensiunii arteriale, prin Arginina care produce efectul de vasodilatatie (Relaxing).

- Cardiopatie ischemica: O reducere a concentratiei de Coenzima Q10 are cu sine o tulburare miocardica datorata unei insuficiente in fluxul sanguin coronarian cu o reducere de 20 %, cea ce are din nou ca rezultat neasigurarea oxigenarii miocardice, asigurarea cu factori bioenergetici, compenseaza insuficienta in fluxul sanguin coronarian.

- Coenzima Q10 continut in mitocondrie care este uzina energetica a materiei vii, Prof.Langsjoen P. H, Prof. Folkers K.au aratat prin adaosul de Coenzima Q10 si L-Carnitina (Dr.Ghidini) o cresterea la normal, din minusul de 20 % a fluxului sanguin coronarian.

15Coenzima Q10 Coenzima Q10 cu efect pozitiv in terapia de cardiopatie ischemica si hipertensiune

16Coenzima Q10 Coenzima Q10 are efect de protectie in ischemia miocardica

- Aritmia lipsa substantelor vitale de Magneziu (Dr.England, Dr.Turlapy), Coenzima Q10 (Prof.Langsjoen P. H, Prof. Folkers K), L-Carnitina (Dr.Rizzon) este cauza aratata in referintele stiintifice.

17Chlorella Chlorella cu continutul de CGF (Chlorella Growth Factor) regleaza ritmul cardiac in aritmie

18Coenzima Q10 Coenzima Q10 cu efect pozitiv un exercitiu toleranta la angina pectorala

Lezarea arterelor coronare prejudiciaza hranirea muschiului inimii, asa cum se intimpla in bolile cunoscute sub numele de angina pectorala, infarct miocardic, cardiopatie ischiemica.

19Coenzima Q10 Coenzima Q10 cu cresterea cantitatii in mitocondrie are efect de protectie cerebrala.

20Coenzima Q10 Coenzima Q10 indicat la pacienti cu boli cardiace, studiu randomizat, dublu-orb, placebo controlat

- Se recomanda de la virsta de 20 de ani un adaus de Coenzima Q10 pentru micsorarea sarcinii inimii si o functie normala.

Coenzima Q10 ca supliment nutritiv

Supliment nutritiv

21Ceai Verde Ceaiul Verde cu continutul de vitamina C si flavonoizi un antioxidant puternic, indicat la boala coronariana

22Ceai Verde Ceaiul verde si extractul de ceai verde epigallocatechin gallate (EGCG) indicat in tratamentul antitrombotic

23Epigallocatechin gallate Extractul de ceai verde epigallocatechin gallate (EGCG) cu actiune antioxidanta reduce placa aterosclerotica

 

Bibliografie-Referinte:
Bibliografie-Referinte

1. Ursini T., Gambini C., Paciaroni E., and Littarru G.P. Coenzyme Q10 treatment of heart failure in the elderly: Preliminary results. In: Biomedical and Clinical Aspects of Coenzyme Q, vol. 6 (1991) Folkers K., Yamagami T., Littarru G. P. Elsevier, Amsterdam, pp 473-480.
2. Ernster L. (1977) Facts and ideas about the function of coenzyme Q10 in the Mitochondria. In: Folkers K., Yamamura Y. (eds) Biomedical and Clinical Aspects of Coenzyme Q. Elsevier, Amsterdam, pp 15-8.
3. Ghirlanda G., Oradei A., Manto A., Lippa S., Uccioli L., Caputo S., Greco A.V., Littarru G.P. (1993) Evidence of Plasma CoQ10 - Lowering Effect by HMG-CoA Reductase Inhibitors: A double blind , placebo-controlled study. Clin. Pharmocol., J. 33, 3, 226-229.
- Littarru G.P., Lippa S., Oradei A., Fiorni R.M., Mazzanti L. Metabolic and diagnostic implications of blood CoQ10 levels. In: Biomedical and Clinical Aspects of Coenzyme Q, vol. 6 (1991) Folkers K., Yamagami T., and Littarru G. P. Elsevier, Amsterdam, pp 1-555.
- Pozzi F, Longo A, Lazzarini C, Carenzi A. Formulations of ubidecarenone with improved bioavailabiltity. Eur J Pharm Biopharm. 1991; 37:243-246.
4. Ernster L., and Forsmark P Ubiquinol : an endogenous antioxidant in aerobic organisms. Seventh International Symposium on Biomedical and Clinical Aspects of Coenzyme Q10 Folkers K., et al (Eds) The Clin Inves 1993 ; Suppl 71 (8): S60-S65.
- Aryoma O. Free Radicals And Antioxidant strategies in sports.J Nutr Biochem 1994 5:370
- Lockwood K., Moesgaard S., Hanioka T., Folkers K. Apparent partial remission of breast cancer in high risk patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med 1994;15 Suppl:s231-40.
- Ingold K.U., Bowry V.W., Stocker R.Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein. Proc Natl Acad Sci U SA 1993 Jan 1;90(1):45-9.
- Lass A, Sohal RS. Effect of coenzyme Q10 and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals. FASEB J. 2000; 14:87-94.
- Tomasetti M, Littaru GP, Stocker R, Alleva R. Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes. Free Rad Biol Med. 1999; 27:1027-1032.
5. Littarru G.P., Ho L., Folkers K. (1972) Deficiency of Coenzyme Q10 in human heart disease. Part I and II. In: Internat. J. Vit. Nutr. Res., 42, n. 2, 291:42, n. 3:413.
- Mortensen S.A., Vadhanavikit S., Folkers K. (1984) Deficiency of coenzyme Q10 in myocardial failure. In: Drugs Exptl. Clin. Res., vol. X(7), pp 497-502.
- Lampertico M, Comis S. Italian multicenter study on the efficacy and safety of coenzyme Q10 as adjuvant therapy in heart failure. Clin Investig. 1993; 71 (Suppl):S129-S133.
- Hofman-Bang C, Rehnqvist N, et al. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 study group. J Card Fail. 1995; 1: 101-107.
- Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multi-center randomized study. Clinic Investig. 1993; 71(Suppl):S134-S136.
- Baggio E, Gandini R, Plancher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med. 1994; 15(Suppl):287-294.
6. Mellstedt H., Osterborg A., Nylander M., Morita M., and Folkers K. A deficiency of coenzyme Q10 (CoQ10) in conventional cancer therapy and blood levels of CoQ10 in cancer patients in Sweden. In: Eighth International Symposium on Biomedical and Clinical Aspects of Coenzyme Q (1994) The Molecular Aspects of Medicine, in print.
7. Henriksen JE, Andersen CB, Hother-Nielsen O, et al. Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with type 1 diabetes mellitus. Diabet Med. 1999; 16:312-318.
8. Folkers K., Langsjoen P. H., et al. (1988) Biochemical deficiencies of coenzyme Q10 in HIV-infection and the exploratory treatment. Biochemical and Biophysical Research Communications vol. 153, no. 2, pp 888-896.
- Folkers K. Critique of 30 years of research on hematopoietic and immunological activities of coenzyme Q10 and potentiality for therapy of AIDS and cancer. Med Chem Res. 1992; 2:48-60.
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9.Hansen I.L. (1976) Bioenergetics in clinical medicine. Gingival leucocytic deficiencies of coenzyme Q10 in patients with periodontal disease. In: Research Communications in Chemical Pathology and Pharmacology, vol. 14, no. 4, pp 729-738.
- Hanioka T, Tanaka M, Oijima M, et al. Effect of topical application of coenzyme Q10 on adult periodontitis. Molec Aspects Med. 1994; 15 (suppl):S241-S248.
- Watts TLP. Coenzyme Q10 and periodontal treatment: is there any beneficial effect? Br Dent J. 1995; 178:209-213
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- Langsjoen Per.H., Vadhanavikit S., Folkers K. (1985) Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. In: Proc. Natl. Acad. of Sci., U.S.A., vol. 82, pp 4240-4244.
- Langsjoen P.H., Folkers K., Lyson K., Muratsu K.Effective and safe therapy with coenzyme Q10 for cardiomyopathy. In: Klin. Wochenschr. (1988) 66:583-593.
- Langsjoen P. H., Langsjoen, P. H., Folkers, K. (1989) Long term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. In: The American Journal of Cardiology, vol. 65, pp 521 - 523.
- Poggessi L., Galanti G., Comeglio M.1991 Effect of coenzyme Q10 on left ventricular function in patients with dilative cardiomyopathy. Curr. Ther. Res. 49: 878-886.
- Hanaki Y, Sugiyama S, Ozawa T, Ohno M. Coenzyme Q10 and coronary artery disease. Clin Investig. 1993; 71 (suppl):S112-S115.
12. Johnston, C.S. "Recommendations for Vitamin C Intake," JAMA, vol. 282, no. 22 (December 1999).
- Jha, P., et al., "The Antioxidant Vitamins and Cadiovascular Disease," Ann. Of Intern. Med., vol. 123 (1995), pp. 860.
- Ginter E 1977. the Role of Vitamin C and Cholesterol, in Re-evaluation of Vitamin C Hrsg. A. Hanck und G. Ritzel, H. Huber, Bern S. 53-56
- Fidanza, A. et al. Vitamin C and cholesterol. Int. J. Vit. Nutr. Res. 1982; 23:153-171.
- Ginter, E. et al. Effect of ascorbic acid on plasma cholesterol in humans in a long-term-experiment. Int. J. Vit. Nutr. Res. 1977; 47: 123134.
- Hornig, D., Weiser, H. Ascorbic acid and cholesterol: effect of graded oral intakes on cholesterol conversion to bile acid in guinea-pigs. Expenenta 1976; 32: 687-689.
13. Jialal, I., Fuller, C.J. Effect of vitamin E, Vitamin C and beta-carotene on LDL oxidation and atherosclerosis. Canad. J. Cardiol. 1995; 11, (Suppl G): 97-103.
- Chamiec, T., Herbaczynska-Cedro, K., Ceremuzynski, L. Effects of antioxidant vitamin C and E on signal-averaged electrocardiogram in acute myocardial infarction Am. J. Cardiol.1996; 77, 4: 237-241.
14. Stocker R, Bowry VW, Frei B. Ubiquinol protects human low-density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci USA. 1991; 88:1646-50.
- Schaefer, E. J., et al., " Lipoprotein(a) Levels And Risk of Coronary Heart Disease in Men," J. of the Amer. Med. Assoc. vol. 271 (1994), pp. 999.
- Turley, S., "The Role of Ascorbic Acid in the Regulation of Choloesterol Metabolism and in the Pathogenesis of Atherosclerosis," Atherosclerosis, vol. 24 (1976), pp. 1.
15. Rossi E., Lombardo A., Testa M., Lippa S., Oradei A., Littarru G.P., Lucente M. Coppola E., Manzoli U. Coenzyme Q10 in ischaemic cardiopathy. In: Biomedical and Clinical Aspects of Coenzyme Q, vol. 6 (1991) Folkers K., Yamagami T., and Littarru G. P. (eds) Elsevier, Amsterdam, pp 321-326.
- Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the protective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci USA. 1985; 82:901-904.
- Fraser, G.E., "Determinants of Ischemic_Heart_Disease in the Seventh Day Adventists: A Review," Am. J. Clin. Nutr., vol. 48 (1988), pp. 833-836.
16. Langsjoen Per H., Langsjoen Peter H., Folkers K. Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment. In: Seventh International Symposium on Biomedical and Clinical Aspects of Coenzyme Q. Folkers, K., Mortensen S.A., Littarru G.P., Yamagami T., and Lenaz G. (eds) The Clinical Investigator, (1993) 71:S 140-S 144.
- Atar D, Mortensen SA, Flachs H, Herzog WR. Coenzyme Q10 protects ischemic myocardium in an open-chart swine model. Clin Investig. 1993; 71(Suppl):S103-S111.
17. Reports from the: Kanazawa Medical University Dept. Of Serology from1985-1992 Include: Regulat ion of Heartbeat Bradycardic Effect by CGF (Chlorella Growth Factor).
18. Hiasa Y., Ishida T., Maeda T., Iwanc K., Aihara T., and Mori H. (1984) Effects of coenzyme Q10 on exercise tolerance in patients with stable angina pectoris. In: Biomedical and Clinical Aspects of Coenzyme Q, vol. 3 (1981) Folkers K., Yamamura Y., (eds) Elsevier, Amsterdam, pp 291-301.
- Kamikawa T., Kobayashi A., Yamashita T., Hayashi H.1985 Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. In: Am. J. Cardiol.; 56:247-251.
19. Matthews RT, Yang L, Browne S, et al. Coenzyme Q10 administration increases mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA. 1998; 95:8892-8897.
20. Schneeberger W., Muller-Steinwachs J., Anda L.P., Fuchs W., Zilliken F., Lyson K., Muratsu K., and Folkers K. A clinical double blind and crossover trial with coenzyme Q10 on patients with cardiac disease. In: Biomedical and Clinical Aspects of Coenzyme Q, vol. 5 (1986) Folkers K., Yamamura Y., (eds) Elsevier, Amsterdam, pp 325-333.
- Langsjoen H.A., Langsjoen P. H., Willis R., Folkers K. (1994) Usefulness of coenzyme Q10 in clinical cardiology, a long-term study. In: Eighth International Symposium on Biomedical and Clinical Aspects of Coenzyme Q, Littarru G.P., Battino M. , Folkers K. (Eds) The Molecular Aspects of Medicine, Vol. 15 (Supplement), pp S165-S175.
- Folkers K, Mortensen SA, Littarru GP, Yamagami T, Lenaz G, eds. The biochemical and clinical aspects of coenzyme Q10. Clin Investig. 1993; 71(Suppl):S51-S178.
- Crane FL, Sun IL, Sun EE. The essential functions of coenzyme Q10. Clin Investig. 1993; 71(Suppl):S55-S59.
21. MGL Hertog, EJM Feskens, PCH Hollman, et al. Dietary antioxidant flavonoids and risk of coronary heart disease. Lancet 1993:342:1007-11.
22. Kang WS, Lim IH, Yuk DY, et al. Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate. Throm Res. 1999; 96:229-237.
23. Chyu KY, Babbidge SM, Zhao X, Dandillaya R, Rietveld AG, Yano J, Dimayuga P, Cercek B, Shah PK. Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice. Atherosclerosis Research Center, Division of Cardiology, and Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine at the University of California, Los Angeles, CA 90048, USA.Circulation. 2004 May 25;109(20):2448-53. Epub 2004 May 10.

Literatura:

- Sinatra, S.T., The Coenzyme Q10 Phenomenon, (New Canaan: Keats Publishing Inc., 1998)

Coenzima Q10



 
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