Gheara Matei Antioxidant
Gheara Matei -
Cat`s Claw Antioxidant
Gheara Matei Anti-cancer
Gheara Matei (Uncaria tomentosa) - foto
Familia: Rubiaceae
Genul: Uncaria
Specia: Tomentosa
Gheara Matei - Cat`s Claw din: Farmacia Naturala
1 Gheara Matei (Uncaria tomentosa) - Cat`s Claw cu proprietati antivirale si
imunomodulatoare.
2 Gheara Matei - Cat`s Claw cu proprietati de
reparatie a sistemului imunitar.
3 Gheara Matei - Cat`s Claw
stimuleaza producerea de interleukina 1 si interleukina 6.
4 Gheara Matei - Cat`s Claw pentru imunitate
5 Gheara Matei - Cat`s ca regulator de expresia citokinele inflamatorii
TNF-alfa, IL-1beta
6 Gheara
Matei - Cat`s Claw o planta folosita in etno-medicina si farmacologie
7 Gheara
Matei - Cat`s Claw antioxidant cu continut de procianidine are activitate antiinflamatoare
8 Gheara
Matei - Cat`s Claw cu activitate antiinflamatoare si antioxidanta
9 Gheara
Matei - Cat`s Claw cu actiune antiinflamatoare, rolul de NF-kappaB
10 Gheara
Matei - Cat`s Claw indicat in tratamentul de artrita reumatoida
11 Gheara
Matei - Cat`s Claw indicat in tratamentul in catabolismul cartilajului la osteoartrita
12 Gheara
Matei - Cat`s Claw reduce inflamatia in osteoartrita
13 Gheara
Matei - Cat`s Claw planta medicinala din Peru cu potential anti-cancer
14 Gheara
Matei - Cat`s Claw cu efecte
antiproliferative la liniile celulare de cancer mamar
15 Gheara
Matei - Cat`s Claw se leaga de receptorii de estrogen
16 Gheara Matei - Cat`s Claw induce moarte celulara (apoptoza) la celulele
tumorale si inhiba proliferarea
17 Gheara Matei - Cat`s Claw cu efect de pro apoptoza
18 Gheara Matei - Cat`s Claw induce apoptoza in proliferarea de expresia G0/G1
si bcl-2 la celulele de leucemie
19 Gheara
Matei - Cat`s Claw cu sensibilitate la liniile celulare de leucemie
20 Gheara Matei - Cat`s Claw in tratamentul citostatic indus de leucopenia
21 Gheara
Matei - Cat`s Claw cu activitate antimutagenica
22 Efectul
de Gheara Matei - Cat`s Claw la contractia in aorta
23 Efectul
de Gheara Matei - Cat`s Claw la contractia in miocard
24 Gheara
Matei - Cat`s Claw cu analiza electroforetica capilara
25 Gheara
Matei - Cat`s Claw reduce vascozitatea
sangelui scade hipertensiunea arteriala
26 Gheara
Matei - Cat`s Claw cu actiune de vasodilatare
27. Gheara
Matei - Cat`s Claw este
un bun antiagregant, antigoagulant si tromboza
Tromboza venoasa
28 Gheara
Matei - Cat`s Claw cu activitate antivirala
29 Gheara
Matei - Cat`s Claw involvat in receptorii
serotoninici 5-HT2
30 Gheara
Matei - Cat`s Claw un inhibitor de placa amiloida la maladia Alzheimer
Poate suplimente de anti Alzheimer prelungi viata longevitate anti-imbatranire Anti-Aging
| Creier sanatos fara Alzheimer |
Creier cu
Alzheimer |
 |
 |
Placa amiloida la maladia
Alzheimer
31 Gheara
Matei - Cat`s Claw cu actiune farmaceutica in tratarea de boala Alzheimer
32 Gheara
Matei - Cat`s Claw creste reparatia ADN-ului in pielea umana, un produs natural
pentru ingrijirea pielii
33 Gheara
Matei - Cat`s Claw cu evaluare antioxidativa
Miracolul
antioxidant
|
Terapia
Anti-Aging cu antioxidanti
|
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Fountain
of Youth Anti-Aging
|
|
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Antioxidant,
Antioxidanti, Antioxidantii fantana tineretii
|
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34 Teoria
radicalilor liberi in procesul de imbatrinire
Procesul de
imbatranire cu cauzele endogene si exogene
- Radicalii liberi considerati ca mediatori
patologici.
- Formarea de radicali liberi prin: Factorii
exogeni ca poluarea aerului, razele-UV, radiatii ionizante, etc., factorii
endogeni pot fi stres, exercitiu fizic extenuant, inflamatii, fumat, etc.
- Tipuri de radicali liberi: Radicalii
liberi ai oxigenului, Radicalii liberi ai azotului, Radicalul thiil,etc
| Formarea de
radicali liberi |
Structura celulei
este oxidata de actiunea agresiva a radicalilor liberi |
 |
 |
Inalta concentratie de oxigen reactiv - radicalii liberi si cantitatea insuficienta
in organism de antioxidanti, genera in organite (centrale energetice celulare)
eficacitatea scazuta a repararii ADN-ului, ca rezultat: Disfunctia mitocondriala,
care este o caracteristica a celulelor maligne.
35 Gheara
Matei - Cat`s Claw cu activitate antioxidanta un inhibitor de stres oxidativ
| Radicalii liberi
produc stres oxidativ |
Distrugerile
ADN-ului de radicalii liberi care produc stres oxidativ |
 |
 |
Mutatiile ADN-ului de radicalii liberi afecteaza energia celulara
ATP Administrarea de antioxidanti ca factor anti cancer determina reversia
fenotipului malign prin inhibarea celulelor de cancer
| Degradarea ADN-ului
prin acumularea de 8-hidroxi-2’-deoxiguanozina |
Reversia fenotipului
malign prin inhibarea celulelor de cancer |
 |
 |
Neutralizarea
de radicali liberi - Densitatea antioxidativa
Despre antioxidanti: Antioxidantii sint
molecule care apara organismul de efectele oxigenului reactiv - Radicalii
liberi
Radicalii liberi produc stres oxidativ, iar antioxidantii apara celula de radicalii
liberi care sint molecule instabile, contin electroni neimperecheati, adica
un electron ocupa un singur orbital.
36 Gheara
Matei - Cat`s Claw antioxidant cu protectite inhiba productia de TNFalfa si
neutralizarea de radicali liberi
37 Gheara
Matei - Cat`s Claw cu protectie de ozon care induce inflamatia pulmonara
Disfunctia mitocondriala care este o caracteristica
a celulelor maligne, datorat prin capacitatea scazuta antioxidativa.
| Antioxidantii
apara celula de efectele oxigenului reactiv |
Antioxidantii
neutralizeaza radicalii liberi - Capacitate scazuta antioxidativa |
 |
 |
Antioxidanti se gasesc in orice celula,
protejeaza organismul de distrugerile provocate la nivel celular de radicalii
liberi.
Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata,
daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa
Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti
ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa
de efectele radicalilor liberi.
Antioxidantii protejind
celula de radicalii liberi - Capacitate suficienta
| Bibliografie-Referinte: |
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| Informatii din bibliografia electronica la tema: Nutritie si sanatate |
1 Williams JE. Review of
antiviral and immunomodulating properties of plants of the Peruvian rainforest
with a particular
emphasis on Una de Gato and Sangre
de Grado. Alternative Medicine Review. 2001;6(6):567-579.
2 Sheng Y, Bryngelsson C, Pero RW.
Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a
novel aqueous
extract from Uncaria tomentosa.
Journal of Ethnopharmacology. 2000;69(2):115-126.
- Akesson Ch, Pero RW, Ivars
F. C-Med
100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival
in vivo. Sections for Immunology, Department of
Cell
and Molecular Biology, Lund University, Lund, Sweden. Phytomedicine. 2003 Jan;10(1):23-33.
-
Sheng Y, Li L, Holmgren K, Pero RW. DNA
repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer
study. Department of Cell and Molecular
Biology, Section of Tumor and Immune Biology, University of Lund, Sweden.
Phytomedicine. 2001 Jul;8(4):275-82.
3 Lemaire I, Assinewe V,
Cano P, Awang DV, Arnason JT. Stimulation of interleukin-1 and -6 production
in alveolar macrophages by the neotropical liana, Uncaria
tomentosa (una de gato). Journal of Ethnopharmacology. 1999;64(2):109-115.
4 Whitaker, Julian, M.D., "Take Una de
Gato for All-Around Immunity," Health & Healing," May, 1995.
5 Allen-Hall L, Cano P, Arnason JT, Rojas R, Lock O, Lafrenie RM.
Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates
the
expression
if IL-1beta and TNF-alpha. Regional Cancer Program, Sudbury Regional Hospital,
Sudbury, Ont, Canada. J Ethnopharmacol. 2007 Jan 19;109(2):312-7. Epub 2006
Aug 3.
6 Keplinger K, Laus G, Wurm M, Dierich
MP, Teppner H. Uncaria tomentosa (Willd.) DC.--ethnomedicinal
use and new pharmacological, toxicological and botanical results. Immodal
Pharmaka GmbH, Volders, Austria. J Ethnopharmacol. 1999 Jan;64(1):23-34.
- Shi
JS, Yu JX, Chen XP, Xu RX. Pharmacological
actions of Uncaria alkaloids,
rhynchophylline and isorhynchophylline. Department of Pharmacology, Zunyi
Medical
College, 563003, China. Acta Pharmacol Sin. 2003 Feb;24(2):97-101.
-
Blumenthal M. Una de gato (cat’s
claw): rainforest herb gets scientific and industry attention. Whole Foods. 1995:65.
7 Gonçalves C, Dinis T, Batista MT. Antioxidant properties of proanthocyanidins
of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity.
Laboratorio de Farmacognosia, Faculdade de Farmácia and Centro de Estudos Farmacêuticos,
Universidade de Coimbra, 3000-295 Coimbra, Portugal. Phytochemistry. 2005 Jan;66(1):89-98.
8Aquino R, De Feo V, De Simone F, Pizza C, Cirino G. Plant
metabolites. New
compounds and anti-inflammatory activity of Uncaria tomentosa. Dipartimento
di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico
II, Italy. J Nat Prod. 1991 Mar-Apr;54(2):453-9.
- Aguilar JL, Rojas P, Marcelo
A, Plaza A, Bauer R, Reininger E, Klaas CA, Merfort I. Anti-inflammatory
activity of two different extracts of Uncaria tomentosa (Rubiaceae). Microbiology
Department, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano
Heredia, Apartado 4314, Lima 100, Peru.
J Ethnopharmacol. 2002 Jul;81(2):271-6.
- Sandoval M, Okuhama NN, Zhang XJ, Condezo LA,
Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. Anti-inflammatory
and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis)
are independent of their alkaloid
content. Albany Medical College, Center for Cardiovascular Sciences and
Deapertment of Pediatrics, NY 12208, USA. Phytomedicine.
2002 May;9(4):325-37.
9 Sandoval-Chacón M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka
H, Charbonnet RM, Clark DA, Miller MJ. Antiinflammatory actions of cat's claw:
the role of NF-kappaB. LSU Medical Center, Department of Paediatrics and Stanley
S. Scott Cancer Center, New Orleans, LA 70112, USA. Aliment Pharmacol Ther.
1998
Dec;12(12):1279-89.
- Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F. An extract of Uncaria
tomentosa inhibiting cell division and NF-kappa B activity without inducing cell
death. Section for Immunology, Department of Cell and Molecular Biology, BMC
I:13, Lund University, Lund, SE-221 84, Sweden. Int Immunopharmacol. 2003
Dec;3(13-14):1889-900.
10 Mur E, Hartig F, Eibl G, Schirmer
M. Randomized
double blind trial of an extract from the pentacyclic alkaloid-chemotype
of uncaria tomentosa for the treatment of rheumatoid arthritis. Department
of Internal Medicine, Innsbruck University Hospital, Austria.
J Rheumatol. 2002 Apr;29(4):678-81.
11 Piscoya J, Rodriguez Z, Bustamante
SA, Okuhama NN, Miller MJ, Sandoval M. Efficacy
and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms
of action of the species Uncaria guianensis. Universidad Nacional Mayor
de San Marcos, Facultad de Medicina, Lima, Peru. Inflamm Res. 2001 Sep;50(9):442-8.
12 Hardin, S. R. "Cat's claw: An Amazonian
vine decreases inflammation in osteoarthritis." Complement.
Ther. Clin. Pract. 2007 Feb; 13(1): 25-8.
13 Gonzales GF, Valerio LG Jr. Medicinal plants from Peru: a review of plants
as potential agents against cancer. Department of Biological and Physiological
Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones
de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru. Anticancer
Agents Med Chem. 2006 Sep;6(5):429-44.
14 Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza
C. The antiproliferative effects of Uncaria tomentosa extracts and fractions
on
the growth of breast cancer cell line. Oncologia Sperimentale C, Istituto Nazionale
per lo Studio e la Cura dei Tumori, Milano, Italy. Anticancer Res. 2001 Jul-Aug;21(4A):2457-61.
15 Salazar EL, Jayme V. Depletion of specific binding sites for estrogen receptor
by Uncaria tomentosa. Unidad de Investigación Mëdica en Biología de la Reproducción,
Hospital de Gineco Obstetricia Luis Castelazo Ayala IMSS, México, D.F. Proc
West Pharmacol Soc. 1998;41:123-4.
16 Sheng Y, Pero RW, Amiri A, Bryngelsson C. Induction of apoptosis and inhibition
of proliferation in human tumor cells treated with extracts of Uncaria tomentosa.
Department of Cell and Molecular Biology, University of Lund, Sweden. Yezhou.
Anticancer Res. 1998 Sep-Oct;18(5A):3363-8.
17 De Martino, L., et al. "Proapoptotic
effect of Uncaria tomentosa extracts." J. Ethnopharmacol. 2006 Aug; 107(1): 91-4.
18 Bacher N, Tiefenthaler M, Sturm S, Stuppner H, Ausserlechner MJ, Kofler R,
Konwalinka G. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating,
G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. Department
of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Br J Haematol. 2006 Mar;132(5):615-22.
19 Stuppner H, Strum S, Geisen G, et al.
A differential sensitivity of oxindole alkaloids to normal and leukemic
cell lines. Planta Medica. 1993;59(Supplement):A583.
20 Sheng Y, Pero RW, Wagner H. Treatment of chemotherapy-induced leukopenia
in a rat model with aqueous extract from Uncaria tomentosa. Department of Cell
and Molecular Biology, University of Lund, Sweden. Yezhou.
Phytomedicine. 2000 Apr;7(2):137-43.
21 Rizzi R, Re F, Bianchi A, De Feo V, de Simone F, Bianchi L, Stivala LA.Mutagenic
and antimutagenic activities of Uncaria tomentosa and its extracts. Departmento
di Farmacologia, Chemioterapia e Tossicologia Medica, Universita degli Studi
di Milano, Italy. J Ethnopharmacol. 1993 Jan;38(1):63-77.
22 Zhang W,
Liu GX, Huang XN. Effect
of rhynchophylline on the contraction
of rabbit aorta. Chung Kuo Li Hsueh Pao. 1987;8:425-429.
23 Zhang
W, Liu GX. Effects of rhynchophylline on myocardial
contractility in
anaesthetized dogs and cats. Chung Kuo Yao
Li Hsueh Pao. 1986;7:426-428.
24 Stuppner
H, Sturm S, Konwalinka G. Capillary electrophoretic
analysis of oxindole
alkaloids
from Uncaria
tomentosa. J Chromatography. 1992;609:375-80.
25 Shi
JS, Liu GX, Wu Q, Huang YP, Zhang XD. Effects
of rhynchophylline and isorhynchophylline on blood pressure and blood flow
of organs in anesthetized
dogs Department of Pharmacology, Zunyi Medical College, China. Zhongguo
Yao Li
Xue Bao. 1992 Jan;13(1):35-8.
- Horie S, Yano S, Aimi N, Sakai S, Watanabe K. Effects
of hirsutine, an antihypertensive indole alkaloid from Uncaria rhynchophylla,
on intracellular calcium in rat
thoracic aorta. Department of Drug Evaluation and Toxicological Sciences,
Chiba
University, Japan. Life Sci. 1992;50(7):491-8.
26 Zhang
WB, Chen CX, Sim SM, Kwan CY. In
vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and
isorhynchophylline, isolated from the
hook of Uncaria rhynchophylla (Miquel). Department of Medicine, Faculty
of Health Sciences, McMaster University, 1200 Main Street West, Hamilton,
Ontario, L8N
3Z5, Canada. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):232-8.
27 Chen CX, Jin RM, Li YK, Zhong
J, Yue L, Chen SC, Zhou JY. Inhibitory
effect
of rhynchophylline on platelet aggregation and thrombosis. Department of
Pharmacology, Shanghai College of Traditional Chinese Medicine. Zhongguo
Yao Li Xue Bao. 1992
Mar;13(2):126-30.
- Jin RM, Chen CX, Li YK, Xu PK.
Effect of rhynchophylline
on platelet aggregation
and
experimental thrombosis.
Yao Hsueh Hsueh
Pao. 1991;26:246-249.
28 Aquino R, De Simone F,
Pizza C, Conti C, Stein ML.
Plant metabolites. Structure
and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa
and Guettarda platypoda. Dipartimento di Chimica delle Sostanze Naturali, Universitá
di Napoli, Italy. J Nat Prod. 1989 Jul-Aug;52(4):679-85.
29 Jürgensen S, Dalbó
S, Angers P, Santos AR, Ribeiro-do-Valle
RM. Involvement of 5-HT2 receptors
in the antinociceptive effect
of Uncaria tomentosa. Departamento
de Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, Santa
Catarina, Brazil. Pharmacol Biochem Behav. 2005 Jul;81(3):466-77.
30 Castillo, G. "Methods of isolation of amyloid
inhibitory ingredients within Uncaria tomentosa." US Patent No 7,029,710, April, 18, 2006.
Castillo, G. " Methods of isolating amyloid-inhibiting
compounds and use of compounds isolated from Uncaria tomentosa and related plants." US Patent No. 6,929,808, August 16, 2005.
31 Castillo, G., et al. “Pharmaceutical compositions containing Uncaria tomentosa
extract for treating Alzheimer's disease and other amyloidoses." Patent-Pct.
Int. Paol. 1998; 00 33,659: 67pp.
32 Mammone T, Akesson C, Gan D, Giampapa V, Pero RW. A water soluble extract
from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary
organ cultures of human skin. Laboratory of Skin Biology Group, The Estee Lauder
Companies Inc, 125 Pinelawn Road, Melville, NY 11747, USA. Phytother Res. 2006
Mar;20(3):178-83.
33 Desmarchelier C, Mongelli E, Coussio J et al. Evaluation
of the in vitro antioxidant activity in extracts of Uncaria tomentosa. Phytother
Res. 1997;11:254-56.
34 Beckman,
K. & Ames, B. (1998) "The
free radical theory of aging matures" Physiol Rev 78: 548-81
35 Pilarski R, Zieliński H, Ciesiołka D, Gulewicz K. Antioxidant activity
of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC. Institute
of
Bioorganic
Chemistry, Polish Academy of Sciences, Noskowskiego str. 12/14, 61-704
Poznań, Poland. J Ethnopharmacol. 2006 Mar 8;104(1-2):18-23. Epub 2005 Sep
30.
36 Sandoval M, Charbonnet RM, Okuhama NN, Roberts J, Krenova Z, Trentacosti
AM, Miller MJ. Cat's claw inhibits TNFalpha production and scavenges free radicals:
role in cytoprotection. Department of Pediatrics and Center for Cardiovascular
Sciences, Albany Medical College, Albany, NY 12208, USA. Free Radic Biol
Med.
2000 Jul 1;29(1):71-8.
37 Cisneros
FJ, Jayo M, Niedziela L. An Uncaria tomentosa (cat's claw) extract protects mice
against ozone-induced lung inflammation. Department of Biology,
North
Carolina A & T
State University, 1601 E Market St., Greensboro, NC 27411, USA. J Ethnopharmacol.
2005 Jan 15;96(3):355-64.
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Gheara Matei (Uncaria tomentosa) - Cat`s Claw cu proprietati antivirale si imunomodulatoare.
