1 Gotu Kola (Centella asiatica) cu proprietati citotoxice si activitate antitumorala, din familia Umbelliferae cu referinta speciala Centella asiatica (L.).

2 Gotu Kola (Centella asiatica) in tratamentul de insuficienta venoasa.

Procesul de imbatranire cu cauzele endogene si exogene

- Radicalii liberi considerati ca mediatori patologici.

- Formarea de radicali liberi prin: Factorii exogeni ca poluarea aerului, razele-UV, radiatii ionizante, etc., factorii endogeni pot fi stres, exercitiu fizic extenuant, inflamatii, fumat, etc.

- Tipuri de radicali liberi: Radicalii liberi ai oxigenului, Radicalii liberi ai azotului, Radicalul thiil,etc

Formarea de radicali liberi	Structura celulei este oxidata de actiunea agresiva a radicalilor liberi

- Inalta concentratie de oxigen reactiv - radicalii liberi si cantitatea insuficienta in organism de antioxidanti, genera in organite (centrale energetice celulare) eficacitatea scazuta a repararii ADN-ului, ca rezultat: Disfunctia mitocondriala, care este o caracteristica a celulelor maligne.

6 Gotu Kola (Centella asiatica) cu efect cognitiv si prevenire de stresul oxidativ, la bola Alzheimer

Creier sanatos	Creier cu Alzheimer

Radicalii liberi produc stres oxidativ	Distrugerile ADN-ului de radicalii liberi care produc stres oxidativ

- Mutatiile ADN-ului de radicalii liberi afecteaza energia celulara ATP Administrarea de antioxidanti ca factor anti cancer determina reversia fenotipului malign prin inhibarea celulelor de cancer - Anti cancer: EGCG Galatul de epigalocatechina

Degradarea ADN-ului prin acumularea de 8-hidroxi-2’-deoxiguanozina	Reversia fenotipului malign prin inhibarea celulelor de cancer

Neutralizarea de radicali liberi - Densitatea antioxidativa

Despre antioxidanti: Antioxidantii sint molecule care apara organismul de efectele oxigenului reactiv - Radicalii liberi
Radicalii liberi produc stres oxidativ, iar antioxidantii apara celula de radicalii liberi care sint molecule instabile, contin electroni neimperecheati, adica un electron ocupa un singur orbital.

Disfunctia mitocondriala care este o caracteristica a celulelor maligne, datorat prin capacitatea scazuta antioxidativa.

Antioxidantii apara celula de efectele oxigenului reactiv	Antioxidantii cu neutralizarea de radicali liberi - Capacitate scazuta antioxidativa

- Antioxidanti se gasesc in orice celula, protejeaza organismul de distrugerile provocate la nivel celular de radicalii liberi.
- Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata, daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa
- Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa de efectele radicalilor liberi.

Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta

Sint o multime de antioxidanti in extracte de plante naturale, fitofarmaceutice, nutraceutice cu capacite de neutralizare a radicalilor liberi Antioxidanti cheie: Acid Alfa Lipoic, Coenzima Q10, Vitamine: Vitamina C, Vitamina E, Caretenoizi, (beta caroten,alfa caroten, licopen, luteina, zeaxantina) Compusi fenolici: Flavonoizi, polifenoli care confera protectie ridicata antoxidativa

- Suficienti antioxidanti de recomandat: Acid Alfa Lipoic, Ceai Verde EGCG, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H ₂O₂) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari

Spirulina contine superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g

10 Gotu Kola (Centella Asiatica) cu efect in tratamentul de insuficienta venoasa cronica

11Gotu Kola (Centella asiatica) cu activitate antioxidanta indicat la limfom

12 Gotu Kola (Centella asiatica) in tratamentul de edem venos inbunatateste microcirculatia periferica la hipertensiunea venoasa, studiu randomizat dublu orb placebo controlat

13 Microangiopatia induse de zborul cu avionul pe distante medii si lungi: Prevenirea de edeme si alterarea microcirculatiei cu Gotu Kola (Centella asiatica)

14 Gotu Kola (Centella asiatica) in tratamentul de microangiopatia diabetica si edem, studiu prospectiv randomizat dublu orb placebo controlat

15 Gotu Kola (Centella asiatica) in tratarea de hipertensiune venoasa, studiu randomizat dublu orb placebo controlat

16 Gotu Kola (Centella asiatica) in tratarea de hipertensiune venoasa innbunatateste microcirculatia si permeabilitatea capilara

17 Gotu Kola (Centella asiatica) in tratarea de hipertensiune venoasa

18 Gotu Kola (Centella asiatica) cu efect in tratarea de hipertensiune venoasa cronica

19 Evaluarea tratamentului de microangiopatia diabetica cu Gotu Kola (Centella asiatica), studiu prospectiv randomizat dublu orb placebo controlat

20 Gotu Kola (Centella asiatica) cu influenta in sinteza de colagen uman important in cosmetica

21 Gotu Kola (Centella asiatica) in tratamentul de tromboza venoasa, studiu randomizat dublu orb placebo controlat

Tromboza venoasa

22 Gotu Kola (Centella asiatica) in tratamentul de varice si hemoroizi: Reviu optiuni de tratament

23 Gotu Kola (Centella asiatica) si Rodie (Punica granatum) in tratamentul de afectiuni parodontale reduce parodontita cronica, studiu preliminar

Rodie (Punica granatum) in tratamentul de afectiuni parodontale	Rodie - Pomegranate - Acid Elagic

24 Gotu Kola (Centella asiatica) si Rodie (Punica granatum) in terapia de suport la afectiuni parodontale reduce parodontita cronica si pastreaza parodontiul sanatos

25 Gotu Kola (Centella asiatica) cu activitate imunomodulatoare

26 Gotu Kola (Centella asiatica) cu potential imunologic

27 Gotu Kola (Centella asiatica) in vitro cu activitate anti hepatoma la cancer de ficat

28 Gotu Kola (Centella asiatica) in vitro cu efect anti proliferant

29 Gotu Kola (Centella asiatica) cu activitate anti herpes

30 Gotu Kola (Centella asiatica) in vitro inhibitor fungic

31. Gotu Kola (Centella asiatica) cu efect de radioprotectie

32 Gotu Kola (Centella asiatica) cu efect la dermatita indusa de radiatia acuta in radioterapie

33 Gotu Kola (Centella asiatica) cu efect la vindecarea ranilor cu leziuni dermatice

35 Gotu Kola (Centella asiatica) induce nivelul de elevare antioxidanta in vindecarea ranilor

36 Gotu Kola (Centella asiatica) in vitro si in vivo cu activitate de vindecarea ranilor

37 Gotu Kola (Centella asiatica) stimuleaza sinteza de colagen cu cresterea de aminoacidul OH-Pro -Hidroxiprolina ( trans-L-4-hidroxiprolina) si glucozaminoglican, remodeleaza matrixul de colagen in vindecarea ranilor

L-Prolina si L-Lizina inhibitor de colagenaza: Gotu Kola stimuleaza sinteza de colagen

38 Gotu Kola (Centella asiatica) stimuleaza sinteza de colagen in cultura de fibroblast

39 Gotu Kola (Centella asiatica) cu activitate in sinteza de colagen I si III

40 Gotu Kola (Centella asiatica) cu efect la acidul acetic induce ulcer gastric

41 Gotu Kola (Centella asiatica) cu efect reduce stresul la ulcer

42 Gotu Kola (Centella asiatica) cu efect la leziunile gastrice cauzate de etanol

Bibliografie-Referinte:

Informatii din bibliografia electronica la tema: Nutritie si sanatate

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