Procesul de imbatranire cu cauzele endogene si exogene

- Radicalii liberi considerati ca mediatori patologici.

- Formarea de radicali liberi prin: Factorii exogeni ca poluarea aerului, razele-UV, radiatii ionizante, etc., factorii endogeni pot fi stres, exercitiu fizic extenuant, inflamatii, fumat, etc.

- Tipuri de radicali liberi: Radicalii liberi ai oxigenului, Radicalii liberi ai azotului, Radicalul thiil,etc

Formarea de radicali liberi	Structura celulei este oxidata de actiunea agresiva a radicalilor liberi

- Inalta concentratie de oxigen reactiv - radicalii liberi si cantitatea insuficienta in organism de antioxidanti, genera in organite (centrale energetice celulare) eficacitatea scazuta a repararii ADN-ului, ca rezultat: Disfunctia mitocondriala, care este o caracteristica a celulelor maligne.

22 Guarana (Paullinia cupana) cu efect de protectie la degradarea ADN prin stresul oxidativ de radicali liberi

Radicalii liberi produc stres oxidativ	Distrugerile ADN-ului de radicalii liberi care produc stres oxidativ

- Mutatiile ADN-ului de radicalii liberi afecteaza energia celulara ATP Administrarea de antioxidanti ca factor anti cancer determina reversia fenotipului malign prin inhibarea celulelor de cancer - Anti cancer: EGCG Galatul de epigalocatechina

Degradarea ADN-ului prin acumularea de 8-hidroxi-2’-deoxiguanozina	Reversia fenotipului malign prin inhibarea celulelor de cancer

Neutralizarea de radicali liberi - Densitatea antioxidativa

Despre antioxidanti: Antioxidantii sint molecule care apara organismul de efectele oxigenului reactiv - Radicalii liberi
Radicalii liberi produc stres oxidativ, iar antioxidantii apara celula de radicalii liberi care sint molecule instabile, contin electroni neimperecheati, adica un electron ocupa un singur orbital.

Disfunctia mitocondriala care este o caracteristica a celulelor maligne, datorat prin capacitatea scazuta antioxidativa.

Antioxidantii apara celula de efectele oxigenului reactiv	Antioxidantii cu neutralizarea de radicali liberi - Capacitate scazuta antioxidativa

- Antioxidanti se gasesc in orice celula, protejeaza organismul de distrugerile provocate la nivel celular de radicalii liberi.
- Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata, daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa
- Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa de efectele radicalilor liberi.

Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta

Sint o multime de antioxidanti in extracte de plante naturale, fitofarmaceutice, nutraceutice cu capacite de neutralizare a radicalilor liberi Antioxidanti cheie: Acid Alfa Lipoic, Coenzima Q10, Vitamine: Vitamina C, Vitamina E, Caretenoizi, (beta caroten,alfa caroten, licopen, luteina, zeaxantina) Compusi fenolici: Flavonoizi, polifenoli care confera protectie ridicata antoxidativa

- Suficienti antioxidanti de recomandat: Acid Alfa Lipoic, Ceai Verde EGCG, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H ₂O₂) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari

Spirulina contine superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g

Bibliografie-Referinte:

Informatii din bibliografia electronica la tema: Nutritie si sanatate

1 Berube-Parent, S., et al. Effects of encapsulated green tea and guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br. J. Nutr. 2005 Sep; 94(3): 432-6.
2 Andersen, T., et al. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J. Hum. Nutr. Diet. 2001; 14(3): 243–50.
3 Boozer CN, Nasser JA, Heymsfield SB, Wang V, Chen G, Solomon JL. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Obesity Research Center, St Luke's-Roosevelt Hospital Center and Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10025, USA. Int J Obes Relat Metab Disord. 2001 Mar;25(3):316-24.
4 Miura T, Tatara M, Nakamura K, Suzuki I. Effect of guarana on exercise in normal and epinephrine-induced glycogenolytic mice. Department of Clinical Nutrition, Suzuka University of Medical Science, Faculty of Health Science, Mie, Japan. Biol Pharm Bull. 1998 Jun;21(6):646-8.
5 Salvadori MC, Rieser EM, Ribeiro Neto LM, Nascimento ES. Determination of xanthines by high-performance liquid chromatography and thin-layer chromatography in horse urine after ingestion of Guaraná powder. Antidoping Lab-Jockey Club de São Paulo, Brazil. Analyst. 1994 Dec;119(12):2701-3.
6 Lima WP, Carnevali LC, Eder R, Costa Rosa LF, Bacchi EM, Seelaender MC. Lipid metabolism in trained rats: effect of guarana (Paullinia cupana Mart.) supplementation. Department of Cell and Developmental Biology, Institute of Biomedical Sciences, Av. Prof. Lineu Prestes 1524, São Paulo, SP, CEP 05508-900, Brazil. Clin Nutr. 2005 Dec;24(6):1019-28. Epub 2005 Sep 22.
7 Roberts, A. T., et al. “The effect of an herbal supplement containing black tea and caffeine on metabolic parameters in humans.” Altern. Med. Rev. 2005 Dec; 10(4): 321-5.
8 Marx, F., et al. “Analysis of guaraná (Paullinia cupana var. sorbilis). Part 1. HPLC determination of caffeine, theobromine and theophylline in guaraná seeds." Dtsch. Lebenstm. Tundsch. 1985; 81(12): 390–92.
9 Espinola, E. B., et al. “Pharmacological activity of guaraná (Paullinia cupana Mart.) in laboratory animals.” J. Ethnopharmacol. 1997; 55(3): 223–29.
10 Bempong DK, Houghton PJ. Dissolution and absorption of caffeine from guarana. Chelsea Department of Pharmacy, King's College London, UK. J Pharm Pharmacol. 1992 Sep;44(9):769-71.
11 Benoni H, Dallakian P, Taraz K. Studies on the essential oil from guarana. Institut für Organische Chemie der Universität Köln, Köln, Germany. Z Lebensm Unters Forsch. 1996 Jul;203(1):95-8.
12 Haskell CF, Kennedy DO, Wesnes KA, Milne AL, Scholey AB. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, UK. J Psychopharmacol. 2007 Jan;21(1):65-70. Epub 2006 Mar 13.
13 Kennedy DO, Haskell CF, Wesnes KA, Scholey AB. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, NE1 8ST, United Kingdom. Pharmacol Biochem Behav. 2004 Nov;79(3):401-11.
14 Galduróz JC, Carlini EA. The effects of long-term administration of guarana on the cognition of normal, elderly volunteers. Brazilian Information Center on Psychotropic Drugs of the Department of Psychobiology, Federal University of São Paulo, Brazil. Sao Paulo Med J. 1996 Jan-Feb;114(1):1073-8.
15 Fukumasu H, da Silva TC, Avanzo JL, de Lima CE, Mackowiak II, Atroch A, de Souza Spinosa H, Moreno FS, Dagli ML. Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaraná, on mouse hepatocarcinogenesis. Laboratory of Experimental Oncology, Department of Pathology, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr Orlando Marques de Paiva, 87. CEP 05508-900 São Paulo, SP, Brazil. Cancer Lett. 2006 Feb 20;233(1):158-64.
16 Fukumasu H, Avanzo JL, Nagamine MK, Barbuto JA, Rao KV, Dagli ML. Paullinia cupana Mart var. sorbilis, guaraná, reduces cell proliferation and increases apoptosis of B16/F10 melanoma lung metastases in mice. Laboratório de Oncologia Experimental e Comparada, Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brasil. Braz J Med Biol Res. 2008 Apr;41(4):305-10
17 Bydlowski SP, Yunker RL, Subbiah MT. A novel property of an aqueous guaraná extract (Paullinia cupana): inhibition of platelet aggregation in vitro and in vivo. Departamento de Ciências Fisiológicas, Faculdade de Ciências Médicas da Santa Casa de São Paulo, Brasil. Braz J Med Biol Res. 1988;21(3):535-8.
18 Bydlowski SP, D'Amico EA, Chamone DA. An aqueous extract of guaraná (Paullinia cupana) decreases platelet thromboxane synthesis. Fundação Pró-Sangue Hemocentro de São Paulo, Faculdade de Medicina, Universidade de São Paulo, Brasil. Braz J Med Biol Res. 1991;24(4):421-4.
19 Campos AR, Barros AI, Santos FA, Rao VS. Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats. Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil. Phytother Res. 2003 Dec;17(10):1199-202.
20 Basile, A., et al. Antibacterial and antioxidant activities of ethanol extract from Paullinia cupana Mart. J. Ethnopharmacol. 2005 Oct; 102(1): 32-6.
21 Beckman, K. & Ames, B. (1998) "The free radical theory of aging matures" Physiol Rev 78: 548-81
22 Fukumasu H, Avanzo JL, Heidor R, Silva TC, Atroch A, Moreno FS, Dagli ML. Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. Laboratory of Experimental Oncology, Department of Pathology, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, CEP 05508-900 São Paulo, SP, Brazil. Food Chem Toxicol. 2006 Jun;44(6):862-7. Epub 2006 Jan 9.

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