IP6 Inositol Hexafosfat Anticancer Anti-Cancer
IP6
Terapia anticancer cu IP6 Inositol Hexafosfat
1 Importanta terapeutica de chelare a fierului: Inhibarea absorbtiei de Fier
prelungeste viata - Longevitate ( prolongs the life span)
2 Terapia
prin chelare: IP 6 un agent chelator cu cation bivalent incarcat electric pozitiv cu afinitate de
atragere a uraniului
3 Terapia
prin chelare: IP6 Inositol Hexafosfat acidul fitic un produs natural cu efect neuroprotector
ca agent chelator la supraincarcarea cu fier in boala Parkinson
Supraincarcarea cu fier vazut la microscop
| Creier cu depuneri de
fier |
Creier fara depuneri
de fier |
 |
 |
4 Terapia prin chelare: Toxicitatea de citokine la precursori de
oligodendrocite este mediata de fier in patogeneza neurodegenerativa la Alzheimer,
Parkinson si Multipla Scleroza
Chelare din lb. gr. chele care inseamna cleste adica atrage
metalele grele prin polarizare, le elimina prin rinichi
5 Terapia
prin chelare: IP6 Inositol Hexafosfat cu actiune de chelare a metalelor grele
ca mercur, plumb, cadmiu, fier, cupru si depunerile de calciu la ateroscleroza
Procesul
de ateroscleroza cu leziunile de aterom si scleroza
|
 |
Procesul aterosclerotic: Cauze, simptome, tratament si profilaxie
 Cauze organice: Din lipsa cronica de Vitamina C in peretii vasculari se formareaza leziuni iar efectele de reparatie a organizmului
compenseaza necontrolat cresterea cu celule musculare si depuneri de Lipoproteina(a)
= apoa in placa aterosclerotica.
Evidenta acumularii Lipoproteinei (apoa) in leziunea aterosclerotica:
- Liproproteina(apoa) are efect de lipire (Adeziune) de peretii vasculari,
nivelul seric crescut de colesterol total, depunerile moleculelor de Calciu
si molecule de zahar (glucoza), participa si ele in ingrosarea prin depuneri
in peretele arterial
- Stenoza este ingustarea lumenului arterial care poate surveni prin
fisurarea ingrosarii, cu depuneri de trombi (cheaguri de sange), vasele de
sange se astupa si intrerupe fluxul sanguin prin formarea de cheaguri (tromboza).
- Simptome: Prezenta aterosclerozei se observa la efort cind nevoia
de oxigen a musculaturii este mai mare iar fluxul de sange scazut.
 Tratament:
Vasodilatori L-Arginina datorita rigidizarii vaselor de sange, fluiditatea singelui Ulei de Peste, Vitamina E,
- Profilaxie: Terapia
prin Chelare a calciului, fierului, aluminiului sau metale grele, apoi mentinerea unui status
de sanatate Anti-Aging - Longevitate
6 Terapia
prin chelare: IP6 Inositol Hexafosfat este un puternic agent chelator pentru
preventia calcificarii in fluidele biologice, necesar in litiaza renala
7. Acidul fitic cu actiune de inhibare de calculi renali
calculilor (pietre la rinichi), calcificarea progresiva care duce la formarea
de pietre
9. IP6 si Inositol ofera protectie impotriva cancerului
10. IP6 Inositol Hexafosfat si Inositol inhiba cancerul de la laborator
in clinica
11. IP6 Inositol Hexafosfat cu acid fitic un citostatic neuronal in
hipocampus
12. IP6 Inositol Hexafosfat un produs natural cu efect anti proliferativ
la cancerul mamar in sinergie cu andriamicina si tamoxifen
13. IP6 Inositol Hexafosfat noul anti-cancer cu functie de inhibare
a celulelor de cancer mamar
14. IP6 Inositol Hexafosfat cu efect in hematopoieza cu formarea de
celule sangvine la leucemie
15. IP6 Inositol Hexafosfat cu activitate de anti angiogeneza
16. IP6 Inositol Hexafosfat induce cresterea celulelor killer, corelat
cu gena supresor tumorala.
17. IP6 Inositol Hexafosfat noul optimizator anticancer, inhiba rabdomiosarcom
in vitro si in vivo
19. Acidul fitic cu protectie de dauna oxidativa ADN cu referinte la
preventia citostatica la cancer
20. IP6 Inositol Hexafosfat dependent de doza inhiba cancerul intestinal
21. IP6 Inositol Hexafosfat cu actiune de anti neoplasm inhiba celulele
de cancer
22. IP6 Inositol Hexafosfat un anti neoplasm, scade profilul lipidic
23. Acidul Fitic - IP6 Inositol Hexafosfat noul optimizator un anti
neoplasm, reviu sistematic
24. IP6 Inositol Hexafosfat cu actiune hipolipidica previne grasimea
la nivel hepatic
25. Acidul Fitic un protector al colonului in peroxidarea lipidica.
26. Acidul Fitic cu efect la nivelul de glucoza sanguina si al unelor
enzime pentru carbohidrati si metabolismul lipidic
27. IP6 Inositol Hexafosfat cu: Fenomen UP (up regulation) reduce stimularea
receptorului genei supresor tumorala p53 si expresia genica WAF1 la carcinomul
de colon HT-29.
29. IP6 Inositol Hexafosfat creste activitatea naturala de celulele
NK, corelat cu inhiba geneza canceroasa
30. IP6 Inositol Hexafosfat in tratamentul de cacer hepatic. IP6 inhiba
cresterea tumorala si transforma fenotipul la linia canceroasa hepatica HepG2.
31. Inositol (myo-Inositol) si IP6 Inositol Hexafosfat in tratamentul de cancer la ficat,
reversia fenotipul malign
la linia canceroasa hepatica HepG2.
32. IP6 Inositol Hexafosfat in tratamentul de cancer 2 la ficat, injectia
intra tumorala cu IP6 cu regres la cancer de ficat
33. IP6 Inositol Hexafosfat si Ceai Verde EGCG la cancerul de pancreas
34. IP6 Inositol Hexafosfat noul optimizator anti-cancer la cancerul
de pancreas
35. IP6 Inositol Hexafosfat induce exocitoza, cresterea productiei celulelor
beta din pancreas
36. IP6 Inositol Hexafosfat cu efect anti-proliferativ la melanomul
malign
37. IP6 Inositol Hexafosfat un supresor la cancerul de prostata
38. IP6 Inositol Hexafosfat un anti-tumoral induce apoptoza celulara
la carcinomul de prostata
39. IP6 Inositol Hexafosfat eficacitate si mecanism de actiune
40. IP6 Inositol Hexafosfat cu efect anti plachetar
Bibliografie-Referinte: IP6 Inositol Hexafosfat
Informatii din bibliografia electronica la tema: Nutritie si sanatate
1. Massie HR, Aiello VR, Williams TR. Inhibition of iron absorption prolongs
the life span of Drosophila. Masonic Medical Research Laboratory, Utica, New
York 13501. Mech Ageing Dev. 1993 Apr;67(3):227-37.
2. Cebrian D, Tapia A, Real A, Morcillo MA. Inositol hexaphosphate: a potential
chelating agent for uranium. Radiobiology Laboratory, Radiation Dosimetry Unit,
Department of Environment, CIEMAT, Avda Complutense 22, 28040 Madrid, Spain.
Radiat Prot Dosimetry. 2007;127(1-4):477-9.
Epub 2007 Jul 12.
3. Xu Q, Kanthasamy AG, Reddy MB. Neuroprotective effect of the natural iron
chelator, phytic acid in a cell culture model of Parkinson's disease. Department
of Biomedical Sciences, Iowa State University, Ames, IA, United States. Toxicology.
2008
Mar 12;245(1-2):101-8. Epub 2007 Dec 27.
4. Zhang X, Haaf M, Todorich B, Grosstephan E, Schieremberg H, Surguladze N,
Connor JR. Cytokine toxicity to oligodendrocyte precursors is mediated by iron.
Department of Neurosurgery, Pennsylvania State University, College of Medicine
Hershey,
PA 17033, USA. Glia. 2005 Nov 15;52(3):199-208.
5. IP6 attaches to heavy metals such as mercury, lead and cadmium, as well as
loose
iron, copper and calcium. J Agriculture Food Chemistry 47: 4714-17, 999
- Phytic acid: new doors open for a chelator. Lancet. 1987 Sep 19;2(8560):664-6.
6. Grases F, Costa-Bauzá A. Phytate (IP6) is a powerful agent for preventing
calcifications in biological fluids: usefulness in renal lithiasis treatment.
Laboratory of Investigation into Renal Lithiasis, Faculty of Sciences, University
of Illes Balears, Palma
de Mallorca, Spain. Anticancer Res. 1999 Sep-Oct;19(5A):3717-22.
7. Grases F, Isern B, Sanchis P, Perello J, Torres JJ, Costa-Bauza A. Phytate
acts as an inhibitor in formation of renal calculi. Laboratory of Renal Lithiasis
Research, University Institute of Health Sciences Research (IUNICS), University
of Balearic Islands, Palma of Mallorca, Spain. Front Biosci. 2007 Jan 1;12:2580-7.
8. Shamsuddin AM, Vucenik I, Cole KE. (1997), "IP6:
A novel anti-cancer agent."; Life Sci 61(4): 343-54.
9. Vucenik I, Shamsuddin AM. Protection against cancer by dietary IP6 and inositol.
Nutr Cancer 2006:55(2):109-25.
10. Vucenik I, Shamsuddin AM. Protection against cancer by dietary IP6 and inositol.
Nutr Cancer 2006:55(2):109-25. Vucenik I, Shamsuddin AM. Cancer inhibition by
inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. Department
of Medical and Research Technology, University of Maryland School of Medicine,
Baltimore, MD 21201, USA. J Nutr. 2003 Nov;133(11 Suppl 1):3778S-3784S.
11. Lees GJ, Leong W. Neuronal cytotoxicity of inositol hexakisphosphate (phytate)
in the rat hippocampus. Department of Psychiatry and Behavioural Science, School
of Medicine, University of Auckland, New Zealand. Brain Res. 1996 Nov 25;741(1-2):134-41.
12. Tantivejkul K, Vucenik I, Eiseman J, Shamsuddin AM. Inositol hexaphosphate
(IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in
breast cancer. Department of Pathology, University of Maryland School of Medicine,
Baltimore, MD 21201, USA. Breast Cancer Res Treat. 2003 Jun;79(3):301-12.
13. Shamsuddin AM, Yang GY, Vucenik I. Novel anti-cancer functions of IP6: growth
inhibition and differentiation of human mammary cancer cell lines in vitro.Department
of Pathology, University of Maryland School of Medicine, Baltimore 21201-1192,
USA. Anticancer Res. 1996 Nov-Dec;16(6A):3287-92.
14. Deliliers GL, Servida F, Fracchiolla NS, Ricci C, Borsotti C, Colombo G,
Soligo D. Effect of inositol hexaphosphate (IP(6)) on human normal and leukaemic
haematopoietic cells. Bone Marrow Transplantation Unit, I.R.C.C.S., Ospedale
Maggiore and University of Milan, Via F. Sforza 35, 20122 Milan, Italy. Br J
Haematol. 2002 Jun;117(3):577-87.
15. Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin
AM. Anti-angiogenic activity of inositol hexaphosphate (IP6). Department of Medical
and Research Technology, University of Maryland School of Medicine, Baltimore,
MD, USA. Carcinogenesis. 2004 Nov;25(11):2115-23. Epub 2004 Aug 5.
16. Baten A, Nabi ZF, Zucker-Franklin D. (1989), "Inositol-phosphate-induced
enhancement of natural killer cell activity correlates with tumor suppression.";Carcinogenesis
10(9): 1595-8.
17. Vucenik I, Kalebic T, Tantivejkul K, Shamsuddin AM. Novel anticancer function
of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and
in vivo. Department of Medical and Research Technology, University of Maryland
School of Medicine, Baltimore 21201, USA. Anticancer Res. 1998 May-Jun;18(3A):1377-84.
18. Graf E, Empson KL, Eaton JW. Phytic acid. A natural antioxidant. J Biol Chem.
1987 Aug 25;262(24):11647-50.
19. Midorikawa K, Murata M, Oikawa S, Hiraku Y, Kawanishi S. Protective effect
of phytic acid on oxidative DNA damage with reference to cancer chemoprevention.
Department of Hygiene, Mie University School of Medicine, Mie, 514-8507, Japan.
Biochem
Biophys Res Commun. 2001 Nov 2;288(3):552-7.
20. Ullah A, Shamsuddin AM. Dose-dependent inhibition of large intestinal cancer
by inositol hexaphosphate in F344 rats. Department of Pathology, University of
Maryland, School of Medicine, Baltimore 21201. Carcinogenesis. 1990 Dec;11(12):2219-22.
21. El-Sherbiny YM, Cox MC, Ismail ZA, Shamsuddin AM, Vucenik I. G0/G1 arrest
and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6).
Department of Clinical Pathology University of Minia School of Medicine, Egypt.
Anticancer Res. 2001 Jul-Aug;21(4A):2393-403.
22. Jariwalla RJ. Inositol hexaphosphate (IP6) as an anti-neoplastic and lipid-lowering
agent. Anticancer Res. 1999;19:3699-3702.
23. Fox CH, Eberl M. Phytic acid (IP6), novel broad spectrum anti-neoplastic
agent: a systematic review. Complement Ther Med 2002;10(4):229-34.
24. Katayama T. Hypolipidemic action of phytic acid (IP6): prevention of fatty
liver. Laboratory of Nutritional Science, Faculty of Education, Hiroshima University,
Japan. Anticancer Res. 1999 Sep-Oct;19(5A):3695-8.
25. Porres JM, Stahl CH, Cheng WH, Fu Y, Roneker KR, Pond WG, Lei XG. (1999),
Dietary intrinsic phytate protects colon from lipid peroxidation in pigs with
a moderately high dietary iron intake.
Proc Soc Exp Biol Med 221(1): 80-6.
26. Dilworth LL, Omoruyi FO, Simon OR, Morrison EY, Asemota HN. The effect of
phytic acid on the levels of blood glucose and some enzymes of carbohydrate and
lipid metabolism. Department of Basic Medical Sciences, The University of the
West
Indies, Kingston 7, Jamaica, West Indies. West Indian Med J. 2005 Mar;54(2):102-6.
27. Saied IT, Shamsuddin AM. (1998), "Up-regulation
of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human
colon carcinoma cell line.";
Anticancer Res 18(3A): 1479-84.
28. Challa A, Rao DR, Reddy BS.(1997), "Interactive
suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic
acid and green tea."; CArcinogenesis 18(10): 2023-6.
29. Zhang Z, Song Y, Wang XL. Inositol hexaphosphate-induced enhancement of natural
killer cell activity correlates with suppression of colon carcinogenesis in rats.
Department of Biochemistry and Molecular Biology, Qingdao University Medical
College, Qingdao 266021, Shandong Province, China. World J Gastroenterol. 2005
Aug 28;11(32):5044-6.
30. Vucenik I, Zhang ZS, Shamsuddin AM. (1998), "IP6
in treatment of liver cancer. IP6 inhibits growth and reverses transformed phenotype
in HepG2 human liver cancer cell line."; Anticancer Res 18(6A): 4083-90.
31. Vucenik I, Tantivejkul K, Zhang ZS, Cole KE, Saied I, Shamsuddin AM. IP6
in treatment of liver cancer. I. IP6 inhibits growth and reverses transformed
phenotype in HepG2 human liver cancer cell line. Department of Medical and Research
Technology, University of Maryland School of Medicine, Baltimore 21201, USA.
Anticancer Res. 1998 Nov-Dec;18(6A):4083-90.
32. Vucenik I, Zhang ZS, Shamsuddin AM. IP6 in treatment of liver cancer. II.
Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted
in nude mice. Department of Medical and Research Technology, University of Maryland
School of Medicine, Baltimore 21201, USA. Anticancer Res. 1998 Nov-Dec;18(6A):4091-6.
33. McMillan B, Riggs DR, Jackson BJ, Cunningham C, McFadden DW. Dietary influence
on pancreatic cancer growth by catechin and inositol hexaphosphate. Department
Of Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown,
West Virginia, USA. J Surg Res. 2007 Jul;141(1):115-9.
34. Somasundar P, Riggs DR, Jackson BJ, Cunningham C, Vona-Davis L, McFadden
DW. Inositol hexaphosphate (IP6): a novel treatment for pancreatic cancer. Louis
A. Johnson VA Medical Center, Clarksburg, West Virginia; Department of Surgery,
West Virginia University, Morgantown, West Virginia, USA. J Surg Res. 2005 Jun
15;126(2):199-203.
35. Høy M, Berggren PO, Gromada J. Involvement of protein
kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic
beta-cells. Laboratory of Islet Cell Physiology, Novo Nordisk A/S, Novo Alle,
DK-2880 Bagsvaerd, Denmark. J Biol Chem. 2003 Sep 12;278(37):35168-71. Epub 2003
Jul 1.
36. Rizvi I, Riggs DR, Jackson BJ, Ng A, Cunningham C, McFadden DW. Inositol
hexaphosphate (IP6) inhibits cellular proliferation in melanoma. Department of
Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown,
West Virginia 26506, USA. J Surg Res. 2006 Jun 1;133(1):3-6. Epub 2006 Mar 23.
37. Singh RP, Sharma G, Mallikarjuna GU, Dhanalakshmi S, Agarwal C, Agarwal R.
In vivo suppression of hormone-refractory prostate cancer growth by inositol
hexaphosphate: induction of insulin-like growth factor binding protein-3 and
inhibition of vascular endothelial growth factor. Department of Pharmaceutical
Sciences, University of Colorado Cancer Center, University of Colorado Health
Sciences Center, Denver, Colorado, USA. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):244-50.
- Diallo JS, Betton B, Parent N, Péant
B, Lessard L, Le Page C, Bertrand R, Mes-Masson AM, Saad F. Enhanced killing
of androgen-independent prostate cancer cells using inositol hexakisphosphate
in combination with proteasome inhibitors. Centre de Recherche du Centre Hospitalier
de l'Université de Montréal (CR-CHUM) and Institut du Cancer de Montréal, Montréal, Québec, Canada. Br J Cancer. 2008 Nov 18;99(10):1613-22. Epub 2008 Oct 21.
38. Singh RP, Agarwal C, Agarwal R. Inositol hexaphosphate inhibits growth, and
induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation
of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Department of Pharmaceutical
Sciences, School of Pharmacy and University of Colorado Cancer Center, University
of Colorado Health Sciences Center, Denver, CO 80262, USA. Carcinogenesis. 2003
Mar;24(3):555-63.
39. Singh RP, Agarwal R. Prostate cancer and inositol hexaphosphate: efficacy
and mechanisms. Department of Pharmaceutical Sciences, School of Pharmacy, University
of Colorado Health Sciences Center, Denver, CO 80262, USA. Anticancer Res. 2005
Jul-Aug;25(4):2891-903.
40. Vucenik I, Podczasy JJ, Shamsuddin AM. Antiplatelet activity of inositol
hexaphosphate (IP6). Department of Medical and Research Technology, University
of Maryland School of Medicine Baltimore 21201, USA. Anticancer Res. 1999
Sep-Oct;19(5A):3689-93.
Parerea din pasajele acestui site nu a fost independent cercetate sau confirmate.
|
