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N-Acetilcisteina

1Acetil-L-Carnitina N-Acetilcisteina numit si Acetilcisteina indicat la bronsitele acute si cronice, BPOC - Bronhopneumopatia cronica obstructiva, studiu randomizat, dublu-orb, placebo controlat

2Acetil-L-Carnitina N-Acetilciseina in tratamentul de prevenire a sindromului de disfunctie organica multipla, studiu randomizat, dublu-orb, placebo controlat


N-Acetilcisteina

N-Acetilcisteina

N-Acetilcisteina

N-Acetilcisteina indical la bronhopneumopatia cronica obstructiva (BPOC)
Bronhopneumopatia cronica obstructiva

N-Acetilcisteina cu grupa tiol-sulfhidril (-SH) este precursor la L-Cisteina, Glutation redus (GSH) un antioxidant puternic

N-Acetilcisteina: Structura chimica
N-Acetilcisteina
N-Acetilcisteina: Formula moleculara: C5H9NO3S
N-Acetilcisteina: Greutatea moleculara: 163.196

3N-Acetilcisteina N-Acetilcisteina efect protectiv la plamin de peroxidarea lipidica, previne sindromul de detresa respiratorie indus de dauna oxidativa a radicalilor liberi

N-Acetilcisteina efect protectiv la plamin
N-Acetilcisteina la plamin

4N-Acetilcisteina N-Acetilcisteina un indirect indicator in tesutul oxigenat la socul septic, studiu randomizat, dublu-orb, placebo controlat

5N-Acetilcisteina N-Acetilcisteina creste circulatia regionala a singelui in ficat inbunatateste functia ficatului la pacienti cu in timpul unui soc septic si soc endotoxic

6N-Acetilcisteina N-Acetilcisteina cu spectru farmacocinetic mult mai larg decit efect mucolitic

N-Acetilcisteina cu spectru farmacocinetic mult mai larg decit efect mucolitic

7N-Acetilcisteina N-Acetilcisteina indicat la scleroza amiotrofica laterala, studiu randomizat, dublu-orb, placebo controlat

8N-Acetilcisteina N-Acetilcisteina cu atomul de hidrogen din grupa tiol (Sulfhidril -SH) poate reduce dauna oxidativa mitocondriala implicata in lezarea memoriei

9N-Acetilcisteina N-Acetilcisteina reduce, Lipoproteina (a) care este un factor de risc in infarctul miocardic

10N-Acetilcisteina N-Acetilcisteina cu efect benefic ca antioxidant dupa infarctul miocardic

11N-Acetilcisteina N-Acetilcisteina si Nitroglicerina in tratamentul de lunga durata in angina pectorala instabila

12N-Acetilcisteina N-Acetilcisteina cu grupa tiol-sulfhidril (-SH) mai efectiva ca Nitroglicerina, in circulatia arteriala si venoasa

13N-Acetilcisteina N-Acetilcisteina in masurarea timpului de protrombina si timpului de tromboplastina la subiecti sanatosi

Tromboza venoasa
Tromboza venoasa

14N-Acetilcisteina N-Acetilcisteina in managementul de boli coronariene

15N-Acetilcisteina N-Acetilcisteina ca antioxidant in tratamentul de chemoterapie la cancer

Celula umana: Structura
Celula umana

16N-AcetilcisteinaTeoria radicalilor liberi in procesul de imbatrinire

 

Densitatea de neutralizare a radicalilor liberi

Celula umana este distrusa prin radicalii liberi:

Capacitate scazuta de neutralizare a radicalilor liberi

Antioxidanti Suficienti antioxidanti de recomandat: Acid Alfa Lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10, N-Acetilcisteina, sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari

Capacitate suficienta de neutralizare a radicalilor liberi

Neutralizarea radicalilor liberi

Antioxidantii neutralizeaza radicali liberi
Antioxidantii

Formarea de radicali liberi
Formarea radicali liberi

Aparat de masurat capacitatea de neutralizare a radicalilor liberi
- Potential redox ORP

17N-Acetilcisteina N-Acetilcisteina cu actiune antioxidanta in reactia cu radicalii liberi

18N-Acetilcisteina Caracterizare intre: N-Acetilcisteina si Ambroxol in terapia antioxidanta

19N-Acetilcisteina N-Acetilcisteina intareste sistemul imunitar, indicat la imunodeficienta-HIV

20N-Acetilcisteina N-Acetilcisteina cu efect anticancer

21N-AcetilcisteinaN-Acetilcisteina cu Vitamina A in tratamentul de cancer de plamin, cancer cerebral, cancer la git, studiu randomizat, dublu-orb, placebo controlat

22N-Acetilcisteina N-Acetilcisteina prin gruparea SH cu efect la terapia de chelatizare prin metilarea de metale grele ca mercur, si efectele toxice de la paracetamol

23N-Acetilcisteina N-Acetilcisteina in tratamentul de intoxicatie si reactii adverse ale medicamentelor

24N-Acetilcisteina N-Acetilcisteina in efectele toxice de la acetaminofen

Poluarea aerului: N-Acetilcisteina inbunatateste respiratia
Poluarea Aerului

25N-Acetilcisteina N-Acetilcisteina ca antidot in intoxicatia cu Amanita phalloides

 

Bibliografie-Referinte:
Bibliografie-Referinte

 

1. Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease Peter N Black , Althea Morgan-Day , Tracey E McMillan , Phillippa J Poole and Robert P Young Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand BMC Pulmonary Medicine 2004, 4:13
- Long-term oral acetylcysteine in chronic bronchitis: Adouble-blind controlled study.Multicenter Study GroupEur. J. Respir. Dis. 61(Sup.):93 (1980)
- Pela R, Calcagni AM, Subiaco S, et al. N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD. Respiration. 1999; 66:495-500.
2. Molnar Z, Schearer E, Lowe D. N-acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized placebo-controlled study. Crit Care Med. 1999; 27:1100-1104.
3. Ortolani O, Conti A, De Gaudio AR, et al. Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome. Shock. 2000; 13:14-18.
- Sala R, Moriggi E, Corvasce G, Morelli D. Protection by N-acetylcysteine against pulmonary endothelial cell damage induced by oxidant damage. Eur Respir J. 1993; 6:440-446.
4. Spies C, Reinhart K, Witt I, Meier-Hellmann A, Hannemann L, Donald L, Bredle PD, Schaffartzik W: Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double-blind study. Crit Care Med 1994, 22:1738-1746.
5. - Rank N, Michel C, Haertel C, Lenhart A, Welte M, Meier-Hellmann A, Spies C: N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med 2000, 28:3799-3807.
- Harrison PM, Wendon JA, Gimson AES, et al. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med. 1991; 324:1852-1857.
- Zhang H, Spapen H, Nguyen DN, Rogiers P, Bakker J, Vincent JL: Effects of N-acetyl-L-cysteine on regional blood flow during endotoxic shock. Eur Surg Res 1995, 27:292-300.
- Ott P: Effects of N-acetylcysteine on hepatic blood flow and function [letter]. Crit Care Med 1998, 26:415.
- Devlin J, Ellis AE, McPeake J, Heaton N, Wendon JA, Williams R: N-acetylcysteine improves indocyanine green extraction and oxygen transport during hepatic dysfunction. Crit Care Med 1997, 26:236-242.
6. Acetylcysteine: A drug that is much more than a mucokinetic.Ziment, I.Biomed. Pharmacother. 42:513-20 (1988)
- The reduction in vitro in viscosity of mucoproteinsolutions by a new mucolytic agent, N-acetylcysteine.Sheffner, A. L.Ann. NY Acad. Sci. 106:288 (1963)
- Holdiness MR. Clinical pharmacokinetics of N-acetylcysteine. Clinical Pharmacokinet. 1991; 20:123-134.
- Clinical pharmacokinetics of N-acetylcysteine.Borgstrom, L., Kagedal, B. and Paulsen, O.Eur. J. Clin. Pharmacol. 31:217-22 (1986)
- Pharmokinetics and bioavailability of reduced and oxidizedN-acetylcysteine.Olsson, B., et al,Eur. J. Clin. Pharmocol. 34:77-82 (1988)
- Pharmacokinetics and bioavailability of oral acetylcysteinein healthy volunteers.De Caro, L., et al,Arzneim.-Forsch/Drug Res., 39:382 (1989)
- Clinical pharmacokinetics of N-acetylcysteine.Holdiness, M. R.Clin. Pharmacokinet. 20:123-34 (1991)
- Jones AL, Jarvie DR, Simpson D, et al. Pharmacokinetics of N-acetylcysteine are altered in patients with chronic liver disease. Aliment Pharmacol Ther. 1997; 11:787-791.
7. Louwerse ES, Weverling GJ, Bossuyt PM, et al. Randomized double-blind controlled trial of acetylcysteine in amyotrophic lateral sclerosis. Arch Neurol. 1995; 52:559-564.
8. Martinez M, Hernandez AI, Martinez N. N-acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondric. Brain Res. 2000; 855:100-106.
9. Lipoprotein(a) reduction by N-acetylcysteine.Hansen, P. R.Lancet 337:672-3 (1991)
- Gavish D, Breslow JL. Lipoprotein (a) reduction by N-acetylcysteine. Lancet. 1991; 337:203-204.
- Lp(a) lipoprotein as a risk factor for myocardialinfarction.Rhoads, G. G., et al,JAMA 256:2540-4 (1986)
10. Beneficial effects of N-acetylcysteine and cysteine instunned myocardium in perfused rat heart.Tang, L-D., et al,Brit. J. Pharmacol. 102(3):601-6 (1991)
11. Ardissino D, Melini PA, Savonitto S, et al. Effect of transdermal nitroglycerin or N-acetylcysteine, or both, in the long-term treatment of unstable angina pectoris. J Am Coll Cardiol. 1997; 29:941-947.
- Hogan JC, Lewis MJ, Henderson AH. Chronic administration of N-acetylcysteine fails to prevent nitrate tolerance in patients with stable angina pectoris. Br J Clin Pharmacol. 1990; 30:573-577.
- Horowitz JD, Henry CA, Syrjanen ML, et al. Nitroglycerine/N-acetylcysteine in the management of unstable angina pectoris. Eur Heart J. 1988; 9 Suppl A:95-100.
- Unverferth DV, Jagadeesh JM, Unverferth BJ, et al. Attempt to prevent doxorubicin-induced acute human myocardial morphologic damage with acetylcysteine. J Natl Canc Inst. 1983; 71:917-920.
12. Ghio S, de Servi S, Perotti R, et al. Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans- effects of N-acetylcysteine administration. Circulation 1992;86:798-802.
13. Jepsen S, Hansen AB. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest 1994;54:543-7.
14. Marchetti G, Lodola E, Licciardello L, Colombo A. Use of N-acetylcysteine in the management of coronary artery diseases. Cardiologia. 1999; 44:633-637.
15. Bongers V, de Jong J, Steen I, et al. Antioxidant-related parameters in patients treated for cancer chemoprevention with N-acetylcysteine. Europ J Cancer. 1995; 31A:921-923.
- Oikawa S, Yamada K, Yamashita N, et al. N-acetylcysteine, a cancer chemopreventive agent, causes oxidative damage to cellular and isolated DNA. Carcinogenesis. 1999; 20:1485-1490.
16. Beckman, K. & Ames, B. (1998) "The free radical theory of aging matures" Physiol Rev 78: 548-81.
17. Aruoma OI, Halliwell B, Hoey BM, Butler B: The antioxidant action of N-acetylcysteine; its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. J Free Radic Biol Med 1989, 6:593-597.
18. Gillissen A, Nowak D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy. Respir Med 1998;92:609-23.
19. De Flora S, Grassi C, Carati L. Attenuation of influence-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur RespirJ. 1997; 10:1535-1541.
- Roederer M, Staal FJT, Raju PA, et al. Cytoline-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc Natl Accd Sci. 1990; 87:4884-4888.
- Kelebic T, Kinter A, Poli G, et al. Suppression of human immunodeficiency virus expression in chronically infected monocyte cells by glutathione, glutathione ester, and N-acetylcysteine. Proc Natl Accd Sci. 1991; 88:986-990.
20. Metabolic, desmutagenic and anticarcinogenic effects ofN-acetylcysteine.De Flora, Silvio, Rossi, G. A. and De Flora, A.Respiration 30(suppl. 1):43-9 (1986)
- In vitro effects of N-acetylcysteine on the mutagenicity ofdirect-acting compounds and procarcinogens.De Flora, Silvio, et al,Carcinogenesis 5(4):505-10 (1984)
- In vivo effects of N-acetylcysteine on glutathionemetabolism and on the biotransformation of carcinogenicand/or mutagenic compounds.De Flora, Silvio, et alCarcinogenesis 6(12):1735-45 (1985)
- Detoxification of genotoxic compounds as a thresholdmechanism limiting their carcinogenicity.De Flora, S.Toxicol. Pathol. 12(4):337-43 (1984)
- Effects of N-acetyl-L-cysteine and ascorbic acid onmutagen-induced chromosomal sensitivity in patients withhead and neck cancers.Trazana, Zoltan, et al,Amer. J. Surg. 162:294-8 (1991)
- Effect of exogenous glutathione on tumor progression in themurine skin multistage carcinogenesis model.Rotstein, J. B. and Slaga, T. J.
- Second-line chemotherapy in small-cell lung cancer.Andersen, M., Kristjansen, P. E. G. and Hansen, H. H.Cancer Treat. Rev. 17(4):427-36 (1990)
- N-acetylcysteine as chemoprotectant in cancer chemotherapy.Martinez, Esteban and Domingo, PereLancet 338:249 (July 27, 1991)
21. van Zandwijk N, Dalesio O, Pastorino U, et al. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. J Natl Cancer Inst 2000;92:977-86.
- van Zandwijk N. N-acetylcysteine for lung cancer prevention. Chest 1995;107:1437-41.
22. Experimental chelation therapy in chromium, lead and boronintoxification with N-acetylcysteine.Tong, T. G.Toxicol. Appl. Pharmacol. 83:142-7 (1986)
- Ballatori N, Lieberman MW, Wang W. 1998. N-acetylcysteine as an antidote in methylmercury poisoning. Environ Health Perspect. 106(5):267-71.
- Dawson AH, et al. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust. 1989; 150:329-331.
- N-acetylcysteine therapy of acute heavy metal poisoning inmice.Henderson, P., et al,Vet. Hum. Toxicol. 27:522-5 (1985)
23. Chyka PA, Butler AY, Holliman BJ, Herman MI. Utility of acetylcysteine in treating poisonings and adverse drug reactions. Drug Saf 2000;22:123-48.
24. Mechanism of action of N-acetylcysteine in the protectionagainst hepatotoxicity of acetaminophen in rats in vivo.Lauterburg, B. H., Corcoran, G. B. and Mitchell, J. R.J. Clin. Invest. 71:980-991 (1983)
25. Montanini S, Sinardi D, Pratico C, et al. Use of acetylcysteine as the life-saving antidote in Amanita phalloides (death cap) poisoning. Case report on 11 patients. Arzneimittel-forschung. 1999; 49:1044-1047.



 
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