9. Sirtuina cu actiune de Longevitate la Saccharomyces cervisiae
Resveratrol cu actiune de Longevitate
10. Resveratrol un activator de Sirtuina mimeaza reducera calorica
si prelungeste imbatrinirea la metazoa
11. Resveratrol cu SRT-501 a primit status de medicament in: Tratamentul de
disfunctie mitocondriala sindromul melas, encefalopatie, acidoza lactica
insotit de episoade
de miopatie mitocondriala (Sirtris Pharmaceuticals.Inc Receives Orphan status
from FDA for Resveratrol)
Resveratrol cu SRT-501 este un activator de Sirtuina 1 patentata.
12. Plante cu continut de polifenoli: Resveratrol si Quercitina care activeaza
sirtuina umana SIRT1: Mecanism
Resveratrol si Quercitina activeaza Sirtuina (SIRT1) o: Longevitate activa care prelungeste viata
13. Sirtuina cu efect de reparatie ADN, un raspuns la dauna ADN
14. Histon deacetilaza (HDAC1) si HSIR2 sint regulatori de longevitate prin
inactivarea de p53 si p21
15. Resveratrol
cu proprietati Anti-Aging, reviu al noului potent antioxidant
pentru ingrijirea pielii
Resveratrol un produs natural pentru ingrijirea pielii, mai mult: Anti Aging Skin Care
Resveratrol din Polygonum cuspidatum Sieb. et Zucc., Fam.Polygonaceae
Nutraceutice - Nutraceuticele Anti Aging Systeme sint din
plante naturale: Farmacia Naturala, care au efecte farmaceutice numite
si fitofarmaceutice.
trans Resveratrol din Polygonum cuspidatum extr. stand.
20%: Farmacia naturala
16. Resveratrol inbunatateste functia in
mitocondrie, protejeaza de boli metabolice prin activarea de Sirtuina -
SIRT1 si PGC-1a
17. Resveratrol un polifenol din grupa fito-alexinelor un
produs natural cu fito-protectie (fitoalexine), creste activitatea endoteliala
de
NO sintaza
Fitoalexine, Fito in gr.= planta si alexine in gr. alexein = protector,
a apara, a veni in ajutor
18. Resveratrol si Quercitina cu actiune vasodilatatie
in
aorta
19. Resveratrol previne alterarea vasculara
20. Resveratrol
creste functia in mitocondria si cu protectie de boli metabolice prin
activarea de Sirtuina - SIRT1
si PGC-1a
Resveratrol activeaza Sirtuina care creste functia mitocondriala, creste rata
metabolica si mimeaza efectul de restrictie calorica
21. Rezveratrol
induce activitatea mitocondriala prin activarea de PGC-1a
22. Resveratrol un activator
de Sirtuina, confera neuroprotectie la multipla scleroza si nevrita optica,
previne degenerarea axonala, neuronala respectiv de invaliditate neurologica
Neuron
Neurotransmitatorii transmit influxul nervos de la neuron spre
neuriti (ramificati de dendrite si axon)
23. Resveratrol ca si Carnosine un Anti-Aging inhiba AGEs induce sinteza
de colagen in celulele musculare netede vasculare la accidentul vascular cerebral
expuse pacientiilor hipertensivi
24. Resveratrol un fitoestrogen care se gaseste in vin, o posibila explicatie
a paradoxului francez
25. Resveratrol un cardioprotector
26. Efectul la trans Resveratrol la
aterogenitate si trombogenitate
27. Efectul de Resveratrol la
agregarea plachetara in vivo si in vitro
28. trans Resveratrol
si Quercitina implicati in protectia bolilor coronariene, blocheaza
agregarea plachetara si sinteza de eicosanoide
29. Resveratrol
si estradiol activeaza rapid receptorii alfa si beta in celulele endoteliale
30. Interactiune
de Resveratrol in protectia de oxidare a LDL-colesterol, interactioneaza
cu mioglobina si peroxinitrit
31. Resveratrol inhiba oxidarea de LDL-colesterol
32. Evaluarea la Resveratrol, Licopene, Curcumina,
Hidroxianisol Butilat (BHA), Esculetina, Mioinositol ca inhibitori in tumorogeneza
la plamini
33. Resveratrol din (Poligonum Cuspidatum) previne crestera tumorala si metastaza
la cancer de plamini deja la o doza minimala de 2,5 mg/kg
34. Rolul de Resveratrol in prevenirea si terapia
de cancer, studii clinice si preclinice
L-Lizina C cu efect de protectie a tesutului conectiv
35. Resveratrol un natural difenol reduce metastaza canceroasa
36. Celulele tumorale circulatoare (CTC) prezice supravietuire la pacientii cu
cancer de prostata metastazat.
Circulatia sangvina a celulelor canceroase
37. Celulele tumorale circulatoare (CTC) versus imaginile obtinute in
urma mamografiei prezice supravietuire la cancerul mamar metastazat.
In testul sagvin pentru cancer se masoara numarul de celule
tumorale circulatoare (CTC) (the number of circulatory tumor cells (CTC)
in the bloodstream)
Test sangvin pentru cancer
L-Lizina inhiba colagenaza care descompune colagenul si favorizeaza metastaza
canceroasa
38. Quercitina cu influenta de apoptoza a celulelor de leucemie
39. Quercitina
interactioneaza sinergic cu Resveratrol in grup genera efectul de sinergie de apoptoza a celulelor de leucemie
40. Resveratrol si Quercitina inhiba
angiogeneza in vitro
41. Resveratrol si
Quercitina creste nivelul plasmatic
de adenozina
42. Resveratrol
si Quercitina cu sinergie moduleaza proliferarea si cresterea celulara
de cacer
bucal
L-Lizina inhiba colagenaza care descompune colagenul si favorizeaza cresterea
celulelor de cancer
43. Resveratrol
inhiba Factorul de crestere
a endoteliului vascular (VEGF) implicat în angiogeneza
44. Resveratrol
cu activitate
anticancer
Resveratrol cu activitate
anticancer
45. Resveratrol
induce
apoptoza si inhiba angiogeneza la cancerul mamar
46. Resveratrol
un produs natural din struguri cu activitate antiestrogenica inhiba cresterea
celulelor canceroase mamare
Resveratrol un produs natural din: Struguri
Chimioterapia cu citostatice la cancer mamar are reactii adverse ca: Astenie fizica, risc de infectii, alopecie, reducerea de cortexul prefrontal
si a volumului hipocampal, cu consecinta a reducerii memoriei, care a fost masurata
cu scara inteligentei
lui D. Wechsler de Masatoshi
Inagaki, M.D., Ph.D studiu
47. Resveratrol
un supresor de DMBA care induce carcinogeneza mamara
48. Resveratrol induce apoptoza dependenta de p53 la
cancerul mamar
49. Resveratrol
inhiba cresterea celulara si induce apoptoza la celulele de cancer ovarian
PA-1
50. Resveratrol cu efect antiproliferativ la cancerul cervical
51. Resveratrol induce apoptoza la
cancerul de prostata
52. Resveratrol induce apoptoza la
carcinom de prostata LNCaP
53. Resveratrol cu efect la
cancerul de prostata
54. Resveratrol induce apoptoza la
limfom folicular
55. Resveratrol induce apoptoza la
adenocarcinomul gastric
56. Resveratrol induce apoptoza
in cancerul gastric
57. Resveratrol
inhiba proliferarea si induce apoptoza in celulele canceroase la pancreas
58. Resveratrol induce apoptoza
in cancer la ochi
59. Resveratrol induce apoptoza
la cancerul tiroidian
60. Resveratrol cu efect antitumoral
la leucemia promielocita
61. Resveratrol un ingredient din vin actioneaza
in leucemia promielocita
62. Resveratrol inhiba cresterea celulelelor de mielom
63. Resveratrol un produs natural din Struguri Rosii
cu activitate
citostatica, induce apoptoza la celule tumorale
64. Resveratrol
cu eficacitate citostatica: Mecanismul molecular
65. Resveratrol cu activitate citostatica la
cancerul de piele
66. Analiza de Resveratrol
ca agent citostatic la cancerul de plamin
70. Resveratrol inhiba tumorogeneza
intestinala cu activitate citostatica
71. Resveratrol cu activitate in
celulele endoteliale
72. trans-Resveratrol antioxidant cu
cu eficienta de actiune in oxidarea in lipozom
73. Resveratrol in preventia cancerului: Reviu a studiilor preclinice
74. Resveratrol prin activarea de sirtuina cu protectie
neuronala la boala Alzheimer
75. Resveratrol promoveaza curatirea de placa amiloida la
boala Alzheimer
Resveratrol promoveaza curatirea
de placa amiloida la boala Alzheimer
76. Resveratrol un potent inhibitor
de Acid arahidonic: Dioxigenaza, lipoxigenaza si prostaglandina E2
77. Resveratrol un anti-aging si anti inflamator, mecanism si implicatii
clinice
Resveratrol un potent inhibitor de Acid arahidonic: Dioxigenaza si
lipoxigenaza
78. Resveratrol in terapia anticancer si anti inflamatoare, cu efect
la
osteoartrita
Resveratrol cu efect la
osteoartrita
79. Resveratrol reduce inflamatia
indusa de colita
80. Resveratrol inhiba la gripa aviara replicarea virusul influentei
aviare din genul influenta
virus tip A
81. Expressia de influenta virus tip A numita gripa spaniola a produs
pandemia din 1918 - 1920 care a cauzat 50 milioane de vieti combinat cu proteina
PB1-F2 creste
patogeneza
virala
si secundar infectia bacteriala de pneumonie
Proteina PB1-F2 are 7 forme, apare
la gripa spaniola, influenta virus H1N1, deranjeaza activitatea din mitocondria
cea ce induce apoptoza celulara.
Proteina PB1-F2 se leaga de proteinele de transport din mitocondria
si induce gaurirea membranei
82. Transmisia de influenta virus este dependenta de temperatura si umuditatea
relativa
83. Resveratrol reduce stresul oxidativ indusa de metale
ca platina
84. Resveratrol cu efect
biologic
85. Resveratrol pe cale orala cu absorbtie
inalta
86. Quercetina in sinergie cu Resveratrol creste biodisponibilitatea,
prin inhibarea procesului de sulfatare
(Sulfation)
Informatii din bibliografia electronica la tema: Nutritie si sanatate
1. Hall SS. Longevity research. In vino vitalis? Compounds activate life-extending
genes. Science. 2003 Aug 29;301(5637):1165.
2. Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Paul
F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical
School, USA. Sci Am. 2006 Mar;294(3):48-51, 54-7.
3. Valenzano DR, Terzibasi E,
Genade T, Cattaneo A, Domenici L, Cellerino A. Resveratrol prolongs lifespan
and retards the onset of age-related markers
in a short-lived vertebrate. Scuola Normale Superiore, 56100 Pisa, Italy. Curr
Biol. 2006 Feb 7;16(3):296-300
4. Pallàs M, Verdaguer E, Tajes M, Gutierrez-Cuesta J, Camins A. Modulation
of sirtuins: new targets for antiageing. Unitat de Farmacologia i Farmacognòsia
i Institut de Biomedicina (IBUB), Facultat de Farmàcia, Universitat de
Barcelona, Nucli Universitari de Pedralbes, E-08028 Barcelona, Spain. Recent
Patents CNS Drug Discov. 2008 Jan;3(1):61-9.
5. Moreno JG, Miller MC, Gross S, et al. Circulating tumor cells predict survival
in patients with metastatic prostate cancer. Urology. 2005 Apr;65(4):713-8.
6. Budd GT, Cristofanilli M, Ellis MJ, et al. Circulating tumor cells versus
imaging--predicting overall survival in metastatic breast cancer. Clin Cancer
Res. 2006 Nov 1;12(21):6403-9.
7. Lamming DW, Wood JG, Sinclair
DA. Small molecules that regulate lifespan: evidence for xenohormesis. Harvard
Medical School, Department of Pathology,
77 Avenue Louis Pasteur, Boston, MA 02115, USA. Mol Microbiol. 2004 Aug;53(4):1003-9.
8. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz
KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian
cell survival by inducing the SIRT1 deacetylase. Department of Pathology,
Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Science.
2004
Jul 16;305(5682):390-2. Epub 2004 Jun 17.
9. Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R., Short-term consumption
of a resveratrol-containing nutraceutical mixture mimics gene expression
of long-term caloric restriction in mouse heart. Experimental Gerontology
2008
Sep;43(9):859-66.
10. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz
KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian
cell survival by inducing the SIRT1 deacetylase. Department of Pathology,
Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Science. 2004
Jul 16;305(5682):390-2. Epub 2004 Jun 17.
11. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin
RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule
activators
of sirtuins extend Saccharomyces cerevisiae lifespan. BIOMOL Research Laboratories,
Inc., 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA. Nature.
2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.
12. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair
D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
Department
of Pathology, Harvard Medical School, 77 Ave. Louis Pasteur, Boston, Massachusetts
02115, USA. Nature. 2004 Aug 5;430(7000):686-9. Epub 2004 Jul 14.
13. Sirtris Receives Orphan Drug Designation from U.S. Food and Drug Administration
for Resveratrol in Mitochondrial Disorder, MELAS Syndrome April 2, 2008
- http://www.lifescience-online.com/?portalPage=Business&issue=SC.04.20080408.99
14. Chart: Biomol. Activation of Sirtuin 1 controled enzymes by various
plant molecules
(polyphenols). Reported in Nature 425:191-6, 2003.
- Borra MT, Smith BC, Denu
JM. Mechanism of human SIRT1 activation by resveratrol. Department of Biomolecular
Chemistry, University of Wisconsin-Madison, Madison,
Wisconsin 53706, USA.J Biol Chem. 2005 Apr 29;280(17):17187-95. Epub 2005
Mar 4.
15. Kruszewski M, Szumiel I.
Sirtuins (histone deacetylases III) in the cellular response to DNA damage--facts
and hypotheses. Department of Radiobiology and
Health Protection, Institute of Nuclear Chemistry & Technology,
Dorodna 16, 03-195 Warszawa, Poland. DNA Repair (Amst). 2005 Nov 21;4(11):1306-13.
Epub 2005 Aug 3.
16. Kim MM, Yoon SO, Cho YS, Chung AS. Histone deacetylases,
HDAC1 and HSIR2, act as a negative regulator of ageing through p53 in human
gingival fibroblast.
Department of Biological Sciences, Korea Advanced Institute of Science
and Technology, Daejeon 305-701, South Korea. Mech Ageing Dev. 2004 May;125(5):351-7.
17.
Richard A Baxter Anti-aging properties of resveratrol: review and report
of a potent new antioxidant skin care formulation Published Online: 31 Jan
2008 Volume 7 Issue 1, Pages 2 - 7
18. Lagouge
M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq
N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx
J. Resveratrol
improves mitochondrial function and protects against metabolic disease
by activating
SIRT1 and PGC-1alpha. Institut de Genetique et de Biologie Moleculaire
et Cellulaire, CNRS / INSERM / ULP, 67404 Illkirch, France. Cell. 2006
Dec 15;127(6):1109-22. Epub 2006 Nov 16.
19. Wallerath T, Deckert G, Ternes
T, Anderson H, Li H, Witte K, Forstermann U. Resveratrol,
a polyphenolic phytoalexin present in red wine, enhances expression and
activity of endothelial nitric oxide synthase. Department of Pharmacology,
Johannes
Gutenberg University, Mainz, Germany. Circulation. 2002 Sep 24;106(13):1652-8. 20. Chen CK, Pace-Asciak CR. Vasorelaxing
activity of resveratrol and quercetin in isolated rat aorta. Research
Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Gen Pharmacol.
1996 Mar;27(2):363-6.
21. Delmas D, Jannin B, Latruffe N. Resveratrol:
preventing properties against vascular alterations and ageing. University
of Burgundy, Laboratory of Molecular and Cell Biology, Dijon, France. Mol
Nutr Food Res. 2005 May;49(5):377-95.
22. Lagouge
M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq
N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx
J. Resveratrol
improves mitochondrial function and protects against metabolic disease
by activating
SIRT1 and PGC-1alpha. Institut de Genetique et de Biologie Moleculaire
et Cellulaire, CNRS / INSERM / ULP, 67404 Illkirch, France. Cell. 2006
Dec 15;127(6):1109-22. Epub 2006 Nov 16.
23. Lagouge M, Argmann C, Gerhart-Hines
Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott
P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol
improves mitochondrial function and protects against metabolic disease
by activating SIRT1 and PGC-1alpha. Institut de Genetique et de Biologie
Moleculaire
et Cellulaire, CNRS / INSERM / ULP, 67404 Illkirch, France. Cell. 2006
Dec 15;127(6):1109-22. Epub 2006 Nov 16.
24. Shindler KS, Ventura E, Rex TS,
Elliott P, Rostami A. SIRT1
Activation Confers
Neuroprotection in Experimental Optic Neuritis. F.M. Kirby Center for Molecular
Ophthalmology, Department of Ophthalmology, University of Pennsylvania Scheie
Eye Institute, Philadelphia, Pennsylvania; the. Invest Ophthalmol Vis Sci.
2007 Aug;48(8):3602-9.
25. Mizutani K, Ikeda K, Yamori Y. Resveratrol inhibits AGEs-induced proliferation
and collagen synthesis activity in vascular smooth muscle cells from stroke-prone
spontaneously hypertensive rats. Life Science, Environmental Conservation
and Development, Graduate School of Human and Environmental Studies, Kyoto
University,
Yosida, Nihonmatu-cho, Sakyo-ku, Kyoto, 6068501, Japan. Biochem Biophys Res
Commun. 2000 Jul 21;274(1):61-7.
26. Kopp, P., 1998. Resveratrol, a phytoestrogen found in red wine. A possible
explanation for the conundrum of the 'French paradox'? Eur. J. Endocrinol.
138, 619-620.
27. Das DK, Maulik N. Resveratrol
in cardioprotection: a therapeutic promise of alternative medicine. Cardiovascular
Research Center, University of Connecticut School of Medicine, Farmington,
CT 06030-1110, USA. Mol Interv. 2006 Feb;6(1):36-47.
- Bradamante S, Barenghi L, Villa A. Cardiovascular
protective effects of resveratrol. CNR-ISTM, Istituto di Scienze e Tecnologie
Molecolari, Via Golgi 19, 20133 Milano, Italy. silvia.bradamante@istm.cnr.it.
Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.
28. Fukao
H, Ijiri Y, Miura M, Hashimoto M, Yamashita T, Fukunaga C, Oiwa K, Kawai
Y, Suwa M, Yamamoto J. Effect
of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein
E-deficient and low-density lipoprotein receptor-deficient mice. Department
of Nutritional Science, Faculty of Food Culture, Kurashiki Sakuyo University,
3515 Nagao, Tamashima, Kurashiki City, Okayama, 710-0292 Japan. Blood
Coagul Fibrinolysis. 2004 Sep;15(6):441-6.
29. Wang Z, Zou J, Huang Y, Cao K,
Xu
Y, Wu JM. Effect
of resveratrol on platelet
aggregation in vivo and in vitro. Department of Cardiology, the First Affiliated
Hospital of Nanjing Medical University, Nanjing 210029, China. Chin Med
J (Engl). 2002 Mar;115(3):378-80.
30. Pace-Asciak CR, Hahn S, Diamandis
EP, Soleas G, Goldberg DM. The
red wine phenolics trans-resveratrol and quercetin block human platelet
aggregation and eicosanoid synthesis: implications for protection against
coronary heart
disease. Department of Pharmacology, University of Toronto, Canada. Clin
Chim
Acta. 1995 Mar 31;235(2):207-19.
31. Klinge CM, Blankenship KA, Risinger
KE, Bhatnagar S, Noisin EL, Sumanasekera WK, Zhao L, Brey DM, Keynton
RS. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen
receptors alpha
and beta in endothelial cells. Department of Biochemistry & Molecular
Biology and Center for Genetics and Molecular Medicine, School of Medicine,
University of Louisville, Kentucky 40292, USA. carolyn.klinge@louisville.edu
J Biol Chem. 2005 Mar 4;280(9):7460-8.
Epub 2004 Dec 22.
32. Brito P, Almeida LM, Dinis TC. The
interaction of resveratrol with ferrylmyoglobin and peroxynitrite; protection
against LDL oxidation. Laboratorio de Bioquimica, Faculdade de Farmacia,
Universidade de Coimbra and Centro de Neurociencias, Couraca dos Apostolos,
51, r/c, 3000-295 Coimbra,
Portugal. Free Radic Res. 2002 Jun;36(6):621-31.
33. Frankel EN, Waterhouse AL, Kinsella
JE. Inhibition
of human LDL oxidation
by resveratrol. Lancet. 1993 Apr 24;341(8852):1103-4.
34. Hecht SS, Kenney PM, Wang M, Trushin
N, Agarwal S, Rao AV, Upadhyaya P. Evaluation
of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol
and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced
lung tumorigenesis in A/J mice. University of Minnesota Cancer Center,
Minneapolis
55455, USA. Cancer Lett. 1999 Apr 1;137(2):123-30.
35. Kimura Y, Okuda H. Effects of naturally occurring stilbene glucosides
from medicinal plants and wine, on tumour growth and lung metastasis
in Lewis lung
carcinoma-bearing
mice. Second Department of Medical Biochemistry, School of Medicine,
Ehime University, Onsen-gun, Japan. J Pharm Pharmacol. 2000 Oct;52(10):1287-95.
36.
Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y.
Role of resveratrol in prevention and therapy of cancer: preclinical and
clinical
studies. Cytokine Research Laboratory, Department of Bioimmunotherapy,
The University of Texas M. D. Anderson Cancer Center, Box 143, 1515 Holcombe
Boulevard, Houston, Texas 77030, USA. Anticancer
Res. 2004 Sep-Oct;24(5A):2783-840.
37. Busquets
S, Ametller E, Fuster G, Olivan M, Raab V, Argiles JM, Lopez-Soriano
FJ. Resveratrol, a natural diphenol, reduces metastatic growth in an experimental
cancer model.
Cancer Research Group, Departament de Bioquimica i Biologia Molecular,
Facultat de
Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain.
Cancer Lett. 2007 Jan 8;245(1-2):144-8. Epub 2006 Feb 7.
38. Mertens-Talcott SU, Talcott ST,
Percival SS. Low
concentrations of quercetin and ellagic acid synergistically influence proliferation,
cytotoxicity and apoptosis in MOLT-4 human leukemia cells. Food Science
and Human Nutrition Department, University of Florida, Gainesville, FL 32611,
USA. J Nutr. 2003 Aug;133(8):2669-74.
39. S. Mertens-Talcott, S. Percival Ellagic acid and quercetin interact synergistically
with resveratrol in the induction of apoptosis and cause transient cell cycle
arrest in human leukemia cells. Department of Food Science and Human Nutrition,
Institute of Food and Agricultural Sciences, University of Florida, P.O. Box
110370, Gainesville, FL 32611-0370, USA Cancer Letters, Volume 218, Issue 2,
Pages 141-151
40. Igura K, Ohta T, Kuroda Y, Kaji
K. Resveratrol
and quercetin inhibit angiogenesis
in vitro. Laboratory of Cell and Molecular Biology of Aging, Graduate School
of Nutritional and Environmental Sciences, University of Shizuoka, Yada,
422-8526, Shizuoka,
Japan. Cancer Lett. 2001 Sep 28;171(1):11-6.
41. Blardi P, De Lalla A, Volpi L,
Di Perri T. Stimulation
of endogenous adenosine release by oral administration of quercetin and
resveratrol in man. Department of Internal Medicine, University of Siena,
Italy. Blardi@unisi.it
Drugs Exp Clin Res. 1999;25(2-3):105-10.
42. ElAttar TM, Virji AS. Modulating
effect of resveratrol and quercetin on oral cancer cell growth and
proliferation. Hormone Research Laboratory, University of Missouri-Kansas
City, School of Dentistry, 64108-2784, USA. virjia@umkc.edu Anticancer
Drugs. 1999
Feb;10(2):187-93.
43. Lin MT, Yen ML, Lin CY, Kuo ML. Inhibition
of vascular endothelial growth factor-induced angiogenesis by resveratrol
through interruption of Src-dependent vascular endothelial cadherin tyrosine
phosphorylation.
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Mol Pharmacol.
2003 Nov;64(5):1029-36.
44. Zhou HB, Chen JJ, Wang WX, Cai
JT, Du Q. Anticancer
activity of resveratrol on implanted human primary gastric carcinoma
cells in nude mice. Department of Gastroenterology, Second Hospital of
Zhejiang
University, Hangzhou 310009, Zhejiang Province, China. zhouhaibohz@163.com
World
J Gastroenterol. 2005 Jan 14;11(2):280-4.
- Azmi AS, Bhat SH, Hadi SM. Resveratrol-Cu(II)
induced DNA breakage in human peripheral lymphocytes: implications for
anticancer properties. Department of Biochemistry, Faculty of Life Sciences,
A.M.U.
Aligarh 202 002, UP, India. FEBS
Lett. 2005 Jun 6;579(14):3131-5.
45. Garvin S, Ollinger K, Dabrosin
C. Resveratrol
induces apoptosis and inhibits angiogenesis in human breast cancer xenografts
in vivo. Division of Gynecologic Oncology, Faculty of Health Sciences,
University Hospital, SE-581 85 Linkoping,
Sweden. Cancer Lett. 2006 Jan 8;231(1):113-22.
46. Lu R, Serrero G. Resveratrol,
a natural product derived from grape, exhibits antiestrogenic activity
and inhibits the growth of human breast cancer cells. Department of Pharmaceutical
Sciences, University of Maryland School of Pharmacy, Baltimore 21201,
USA. J
Cell Physiol. 1999 Jun;179(3):297-304.
- Bhat KP, Lantvit D, Christov K, Mehta
RG, Moon RC, Pezzuto JM. Estrogenic
and antiestrogenic properties of resveratrol in mammary tumor models. Program
for Collaborative Research in the Pharmaceutical Sciences, Department of
Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University
of Illinois at
Chicago, Chicago, Illinois 60612, USA. Cancer Res. 2001 Oct 15;61(20):7456-63.
47. Banerjee S, Bueso-Ramos C, Aggarwal
BB. Suppression
of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats
by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix
metalloprotease
9. Cytokine Research Laboratory, Department of Bioimmunotherapy, The
University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030,
USA. Cancer
Res. 2002 Sep 1;62(17):4945-54.
48. Tang HY, Shih A, Cao HJ, Davis FB,
Davis PJ, Lin HY. Resveratrol-induced
cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer
cells. Research Service, Stratton Veterns Affairs Medical Center, New
York State Department
of
Health, Albany, New York, USA. Mol Cancer Ther.
2006 Aug;5(8):2034-42.
- Huang C, Ma WY, Goranson A, Dong Z. Resveratrol suppresses cell transformation
and induces apoptosis through a p53-dependent
pathway. The Hormel Institute, University of Minnesota, Austin 55912, USA.
Carcinogenesis. 1999 Feb;20(2):237-42.
49. Yang SH, Kim JS, Oh TJ, Kim
MS, Lee SW, Woo SK, Cho HS, Choi YH, Kim YH, Rha SY, Chung HC,
An SW. Genome-scale analysis of resveratrol-induced gene expression profile
in
human
ovarian
cancer cells using a cDNA microarray. Microarray Division, GenomicTree,
Inc., Daejon 305-390, Korea. Int J Oncol. 2003 Apr;22(4):741-50.
50. Zoberi I, Bradbury CM, Curry HA, Bisht KS, Goswami PC, Roti
Roti JL, Gius D. Radiosensitizing and anti-proliferative effects
of resveratrol
in two human
cervical tumor cell lines. Section of Cancer Biology, Mallinckrodt Institute
of Radiology, Washington University School of Medicine, St. Louis, MO,
USA. Cancer
Lett. 2002 Jan 25;175(2):165-73.
51. Benitez DA, Pozo-Guisado
E, Alvarez-Barrientos A, Fernandez-Salguero PM, Castellón
EA. Mechanisms involved in resveratrol-induced apoptosis and cell
cycle
arrest in prostate
cancer-derived
cell lines. Laboratorio de Andrologia Celular y Molocular,
Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas,
Facultad de Medicina, Universidad de Chili, Santiago, Chili. J Androl.
2007 Mar-Apr;28(2):282-93. Epub
2006 Oct 18.
52. Aziz MH, Nihal M, Fu VX,
Jarrard DF, Ahmad N. Resveratrol-caused
apoptosis of human prostate carcinoma LNCaP cells is mediated via
modulation of phosphatidylinositol
3'-kinase/Akt pathway and Bcl-2 family
proteins. Department of Dermatology, University of Wisconsin, 1300 University
Avenue, Medical Science Center B-25, Madison, WI 53706, USA. Mol Cancer
Ther. 2006 May;5(5):1335-41.
53. Kim YA, Rhee SH, Park KY,
Choi YH. Antiproliferative
effect of resveratrol in
human prostate carcinoma cells. Department of Biochemistry, Dongeui University
College of Oriental Medicine and Research Institute of Oriental Medicine,
Pusan National University, Busan,
Korea. J Med Food. 2003 Winter;6(4):273-80.
54. Faber AC, Chiles TC. Resveratrol
induces apoptosis in transformed follicular lymphoma OCI-LY8 cells:
evidence for a novel mechanism involving inhibition of BCL6 signaling.
Department of Biology, Boston College, Chestnut Hill, MA 02467, USA. Int
J Oncol.
2006
Dec;29(6):1561-6.
55. Riles WL, Erickson J, Nayyar
S, Atten MJ, Attar BM, Holian O. Resveratrol
engages
selective apoptotic signals in gastric adenocarcinoma cells. Division of
Gastroenterology, John H. Stroger Hospital of Cook County, 1901 W. Harrison
Street Chicago, IL
60612, USA. World J Gastroenterol. 2006 Sep 21;12(35):5628-34.
56. Atten MJ, Godoy-Romero E,
Attar BM, Milson T, Zopel M, Holian O. Resveratrol
regulates cellular PKC alpha and delta to inhibit growth and induce
apoptosis in gastric cancer cells. Department of Medicine Division of Gastroenterology,
Cook County Hospital, Chicago, IL 60612, USA. Invest New Drugs.
2005 Mar;23(2):111-9.
57. Ding XZ, Adrian TE. Resveratrol inhibits proliferation and
induces apoptosis in human pancreatic cancer cells. Department
of Surgery,
Northwestern University
Medical School, Chicago, Illinois, USA Pancreas. 2002 Nov;25(4):e71-6
58. Sareen
D, van Ginkel PR, Takach JC, Mohiuddin A, Darjatmoko SR, Albert DM, Polans
AS. Mitochondria
as the primary target of resveratrol-induced apoptosis in human retinoblastoma
cells. Department of Biomolecular Chemistry, University of Wisconsin School
of Medicine and Public Health, Madison, WI 53792, USA. Invest Ophthalmol
Vis Sci. 2006 Sep;47(9):3708-16.
59. Shih A, Davis FB, Lin HY,
Davis PJ. Resveratrol
induces apoptosis in thyroid cancer cell lines via a MAPK- and
p53-dependent mechanism. Medical Research Service, Stratton Veterans Affairs
Medical
Center, Albany, New York 12208, USA. J Clin
Endocrinol Metab. 2002 Mar;87(3):1223-32.
60. Saiko P, Horvath Z, Murias
M, Handler N, Jaeger W, Erker T, Fritzer-Szekeres M, Szekeres T.
Antitumor effects of 3,3',4,4',5,5'-hexahydroxystilbene in HL-60 human
promyelocytic leukemia
cells. Clinical Institute of Medical and Chemical Laboratory Diagnostics,
General Hospital of Vienna, Medical University of Vienna, Vienna, Austria.
Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1013-7.
61. Horvath Z, Saiko P, Illmer
C, Madlener S, Hoechtl T, Bauer W, Erker T, Jaeger W, Fritzer-Szekeres
M, Szekeres T. Resveratrol,
an ingredient of wine, acts synergistically with Ara-C and tiazofurin
in HL-60 human promyelocytic leukemia cells. Clinical Institute
of Medical and Chemical Laboratory Diagnostics, General Hospital of
Vienna, Medical University of Vienna, Vienna, Austria. zsuzsanna.Nucleosides
Nucleotides Nucleic Acids. 2006;25(9-11):1019-24.
62. Boissy P, Andersen TL, Abdallah BM, Kassem M, Plesner T, Delaissé JM.
Resveratrol inhibits myeloma cell growth, prevents osteoclast formation,
and promotes osteoblast differentiation. Clinical Research Unit
and Division of
Hematology, Vejle Hospital, Vejle, Southern Denmark University
Network, Denmark. Cancer Res.
2005 Nov 1;65(21):9943-52.
63. Jang M, Cai L, Udeani GO, Slowing
KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta
RG, Moon RC, Pezzuto JM. Cancer
chemopreventive activity of resveratrol, a natural product derived
from grapes. Department of Medicinal Chemistry and Pharmacognosy, College
of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612,
USA.Science. 1997 Jan10;275(5297):218-20.
- Clément, M. V., Hirpara, J. L., Chawdhury, S. H.,
Pervaiz, S., 1998. Chemopreventive agent resveratrol, a natural product derived
from
grapes,
triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood
92, 996-1002.
- Ciolino HP, Yeh GC. Inhibition
of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity
and CYP1A1 expression
by resveratrol. Basic Research Laboratory, Division of Basic Sciences,
National Cancer Institute, Frederick Cancer Research and Development
Center, National
Institutes of Health, Frederick, Maryland 21702-1201, USA. hciolino@mail.ncifcrf.gov
Mol Pharmacol.
1999 Oct;56(4):760-7.
64. Gescher AJ, Steward WP. Relationship
between mechanisms, bioavailibility, and preclinical chemopreventive
efficacy of resveratrol: a conundrum. Cancer Biomarkers and Prevention
Research
Group, Department of Oncology, University of Leicester, Leicester LE2
7LX, United Kingdom. Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):953-7.
- Dong, Z., 2003. Molecular mechanism of the chemopreventive effect
of resveratrol.
Mutat. Res. 523/524, 145-150.
65. Aziz MH, Reagan-Shaw S, Wu J, Longley BJ, Ahmad N. Chemoprevention
of skin cancer by grape constituent resveratrol: relevance to human disease
Department of Dermatology, University of Wisconsin, Madison, WI 53706,
USA. FASEB J. 2005 Jul;19(9):1193-5.
Epub 2005 Apr 18.
-
Joe AK, Liu H, Suzui M, Vural
ME,
Xiao D, Weinstein IB. Resveratrol
induces growth inhibition, S-phase arrest, apoptosis, and changes in
biomarker expression in several human cancer cell lines. Herbert Irving Comprehensive
Cancer Center, Department of Medicine, College of Physicians and Surgeons
of Columbia University, New York, New York 10032, USA. Clin Cancer
Res. 2002 Mar;8(3):893-903.
- Roemer K, Mahyar-Roemer M. The basis for the chemopreventive action
of resveratrol. Department of Virology, University of Saarland Med
School, Homburg/Saar,
Germany.
Drugs Today (Barc). 2002 Aug;38(8):571-80.
66. Berge G, Ovrebo S, Eilertsen
E, Haugen A, Mollerup S. Analysis
of resveratrol as a lung cancer chemopreventive agent in A/J
mice exposed to benzo[a]pyrene. Department of Toxicology, National
Institute of Occupational Health, PO Box 8149 Dep, N-0033 Oslo,
Norway. : Br
J Cancer. 2004 Oct 4;91(7):1380-3.
67. Woo JH, Lim JH, Kim YH, Suh
SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK. Resveratrol
inhibits phorbol myristate acetate-induced matrix metalloproteinase-9
expression by inhibiting JNK and PKC delta signal transduction.
Department of Immunology, School of Medicine, Keimyung University,
194 DongSan-Dong
Jung-Gu, South Korea. Oncogene. 2004 Mar 11;23(10):1845-53.
Am J Physiol Lung Cell Mol Physiol.
2004 Oct;287(4):L774-83. Epub 2004 Jun 4.
68. Li ZG, Hong T, Shimada Y, Komoto
I, Kawabe A, Ding Y, Kaganoi J, Hashimoto Y, Imamura M. Suppression
of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis
in F344 rats by resveratrol. Department of Surgery and Surgical Basic
Science,
Graduate School of Medicine, Kyoto University, 54-Shogoin, Kawahra-cho,
Sakyoku, Kyoto
606-8507, Japan. Carcinogenesis. 2002 Sep;23(9):1531-6.
69. Tessitore L, Davit A, Sarotto
I, Caderni G. Resveratrol
depresses the growth of colorectal aberrant crypt foci by affecting
bax and p21(CIP) expression. Dipartimento di Scienze Chimiche Alimentari
Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale 'Amedeo
Avogadro',
Vercelli,
Italy. tessitor@pasteur.sluigi.unito.it
Carcinogenesis. 2000 Aug;21(8):1619-22.
70. Schneider Y, Duranton B, Gosse
F, Schleiffer R, Seiler N, Raul F. Resveratrol
inhibits intestinal tumorigenesis and modulates host-defense-related
gene expression in an animal model of human familial adenomatous polyposis.
Laboratoire du Controle Metabolique et Nutritionnel en Oncologie Digestive,
l'Universite
Louis
Pasteur, Institut de Recherche contre les Cancers de l'Appareil Digestif,
67091 Strasbourg, France. Nutr Cancer. 2001;39(1):102-7.
71. Ferrero ME, Bertelli AE, Fulgenzi
A, Pellegatta F, Corsi MM, Bonfrate M, Ferrara F, De Caterina R, Giovannini
L, Bertelli A.Activity
in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium.
Institute of General Pathology, Centro di Studio sulla Patologia Cellulare
del Consiglio
Nazionale delle Ricerche, Milan, Italy. mefer@imiucca.csi.unimi.it
Am J Clin Nutr. 1998 Dec;68(6):1208-14.
72. Stojanovic S, Sprinz H, Brede
O. Efficiency
and mechanism of the antioxidant action of trans-resveratrol and its
analogues in the radical liposome oxidation. Research Unit Time-Resolved
Spectroscopy,
University of Leipzig, Permoserstrasse 15, D-04318 Leipzig, Germany.
Arch Biochem Biophys. 2001 Jul 1;391(1):79-89.
73. Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, Kim
AL. Resveratrol: a review of preclinical studies for human cancer prevention.
Department of
Dermatology, College of Physicians and Surgeons, Columbia University, 630
West 168th Street VC15-204, New York, NY 10032, USA. Toxicol Appl Pharmacol.
2007
Nov 1;224(3):274-83.
Epub 2007 Jan 3.
74. Anekonda TS, Reddy PH. Neuronal protection by sirtuins in
Alzheimer's disease. Neurogenetics Laboratory, Neurological Sciences Institute,
Oregon
Health
and Science University, Beaverton, Oregon 97006, USA. J Neurochem. 2006
Jan;96(2):305-13. Epub 2005 Oct 7.
75. Marambaud P, Zhao H, Davies P. Resveratrol
promotes clearance of Alzheimer's
disease amyloid-beta peptides. Litwin-Zucker Research Center for
the Study of Alzheimer's Disease and Memory Disorders, North Shore-Long
Island Jewish Institute
for Medical Research, Manhasset, NY 11030, USA. J Biol Chem. 2005
Nov 11;280(45):37377-82. Epub 2005 Sep 14.
76. Pinto MC, Garcia-Barrado JA,
Macias P. Resveratrol
is a potent inhibitor of the dioxygenase activity of lipoxygenase.
Departamento Bioquimica y Biologia Molecular, Facultad Ciencias,
Universidad de Extremadura,
06080 Badajoz, Spain. J Agric Food Chem. 1999 Dec;47(12):4842-6.
- Young Ae Kim, Gi-Young Kim, Kun-Young Park, Yung Hyun Choi.
Resveratrol Inhibits Nitric Oxide and Prostaglandin E2 Production
by Lipopolysaccharide-Activated
C6 Microglia Journal of Medicinal
Food. June 1, 2007, 10(2): 218-224. doi:10.1089/jmf.2006.143.
77. de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and
anti-aging agent: mechanisms and clinical implications. Department of Pharmacology,
Faculty of Pharmacy, University of Seville, Seville, Spain. Mol Nutr Food
Res.
2005
May;49(5):405-30.
- Donnelly LE, Newton R, Kennedy GE, Fenwick PS, Leung RH, Ito K, Russell
RE, Barnes PJ. Anti-inflammatory effects of resveratrol in lung epithelial
cells:
molecular mechanisms. Department of Thoracic Medicine, National Heart and
Lung Institute, Imperial College London, London SW3 6LY, UK. Am J Physiol
Lung Cell
Mol Physiol. 2004 Oct;287(4):L774-83. Epub 2004 Jun 4.
78. Udenigwe CC, Ramprasath
VR, Aluko RE, Jones PJ. Potential of resveratrol in anticancer and anti-inflammatory
therapy. Department of Human Nutritional
Sciences,
University
of Manitoba, Winnipeg, Manitoba, Canada. Nutr Rev. 2008 Aug;66(8):445-54.
-
Elmali N, Esenkaya I, Harma
A, Ertem K, Turkoz Y, Mizrak B. Effect
of resveratrol in experimental osteoarthritis in rabbits. Department
of Orthopaedics and Traumatology, Inonu University Medical
Faculty, 44069, Malatya,
Turkey. nelmali@hotmail.com Inflamm Res. 2005 Apr;54(4):158-62.
79. Martin AR, Villegas I, Sanchez-Hidalgo
M, de la Lastra CA. The
effects of resveratrol, a phytoalexin derived from red wines,
on chronic inflammation induced in an experimentally induced
colitis
model. Department
of Pharmacology, Faculty of Pharmacy, University of Seville,
Profesor Garcia Gonzalez Street
2, Sevilla 41012, Spain. Br J Pharmacol. 2006 Apr;147(8):873-85.
80. Palamara AT, Nencioni L, Aquilano
K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci
E. Inhibition of influenza A virus replication by resveratrol.
Institute
of Microbiology,
University of Rome La Sapienza, Rome, Italy. annateresa.palamara@uniroma1.it
J Infect Dis. 2005 May 15;191(10):1719-29. Epub 2005 Apr 13.
81. Julie L. McAuley, Felicita Hornung,
Kelli L. Boyd, Amber M. Smith, Raelene McKeon, Jack Bennink,
Jonathan W. Yewdell, and Jonathan A. McCullers, Expression
of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis
of Viral and Secondary Bacterial Pneumonia Department of Infectious
Diseases,
St.
Jude Children's Research Hospital, Memphis, TN 38105, USA Cell
Host
and Microbe, Vol 2, 240-249, 11 October 2007
82. Anice C. Lowen, Samira Mubareka, John Steel, Peter Palese
Influenza Virus
Transmission Is Dependent on Relative Humidity and Temperature Department
of Medicine,
Mount Sinai School of Medicine, New York, United States of America
83. Olas B, Wachowicz B, Majsterek
I, Blasiak J. Resveratrol
may reduce oxidative stress induced by platinum compounds in
human plasma, blood platelets and lymphocytes. Department of General
Biochemistry,
Institute of Biochemistry, University of Lodz, Poland. olasb@biol.uni.lodz.pl
Anticancer Drugs. 2005 Jul;16(6):659-65.
84. Fremont L. Biological
effects of resveratrol. Laboratoire de Nutrition et Securite Alimentaire
INRA-CRJ, Jouy-en-Josas, France. Life Sci. 2000 Jan 14;66(8):663-73.
85. Walle T, Hsieh F, DeLegge MH,
Oatis JE Jr, Walle UK. High
absorption but very low bioavailability of oral resveratrol in
humans. Department of Cell and Molecular Pharmacology and Experimental
Therapeutics,
Medical
University of South Carolina, Charleston, SC 29425, USA. wallet@musc.edu
Drug Metab Dispos. 2004 Dec;32(12):1377-82. Epub 2004 Aug 27.
86. De Santi C, Pietrabissa A, Spisni
R, Mosca F, Pacifici GM. Sulphation
of resveratrol, a natural product present in grapes and wine,
in the human liver and duodenum. Department of Neurosciences,
Medical School,
Pisa,
Italy.
Xenobiotica. 2000 Jun;30(6):609-17.
Parerea din pasajele acestui site nu a fost independent cercetate sau confirmate.
Resveratrol Sinergie este o formula avansata anti cancer cu fitofarmaceutice ca: 1 Fl. Formula 1 = trans Resveratrol extr. stand. 50%, 25 mg din (Poligonum cuspidatum), Extract din Samburi de Struguri extr.stand. OPC 95% din: Saminta de Struguri Rosii (Vitis Vinifera), 150 mg, Quercitina extr. stand. 98% 100 mg, Acid Elagic 40% 125mg, + 1 Fl. Formula 2 = Ceai Verde Supreme extr. stand. EGCG 40%, 400 mg, Vitamina C 100 mg.
