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20
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| Formarea de radicali liberi | Structura celulei este oxidata de actiunea agresiva a radicalilor liberi |
 |
 |
- Inalta concentratie de oxigen reactiv - radicalii liberi si cantitatea insuficienta in organism de antioxidanti, genera in organite (centrale energetice celulare) eficacitatea scazuta a repararii ADN-ului, ca rezultat: Disfunctia mitocondriala, care este o caracteristica a celulelor maligne.
21
Chimia
la catechine antioxidanti inhiba stresul oxidativ,
reactia la EGCG galatul de epigalocatechina cu radicalul peroxil
(ROO-)
| Radicalii liberi produc stres oxidativ | Distrugerile ADN-ului de radicalii liberi care produc stres oxidativ |
 |
 |
- Mutatiile ADN-ului de radicalii liberi afecteaza energia celulara ATP Administrarea de antioxidanti ca factor anti cancer determina reversia fenotipului malign prin inhibarea celulelor de cancer - Anti cancer: EGCG Galatul de epigalocatechina
| Degradarea ADN-ului prin acumularea de 8-hidroxi-2’-deoxiguanozina | Reversia fenotipului malign prin inhibarea celulelor de cancer |
 |
 |
Neutralizarea de radicali liberi - Densitatea antioxidativa
Despre antioxidanti: Antioxidantii sint molecule care
apara organismul de efectele oxigenului reactiv - Radicalii liberi
Radicalii liberi produc stres oxidativ, iar antioxidantii apara celula
de radicalii liberi care sint molecule instabile, contin electroni neimperecheati,
adica un electron ocupa un singur orbital.
22 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% are activitate antioxidanta de neutralizare de radicali liberi:
radicalul superoxid (O2-), radicalul
peroxil (RO2-), radicalul peroxinitrit (OONO -),
peroxid de hidrogen (H2O2) previne oxidarea
LDL - biologia si medicina radicalilor liberi
23 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% are activitate
antioxidanta de neutralizare a
radicalilor liberi, inhiba peroxidarea lipidelor, degradarea
ADN-ului, in 8-hidroxi-2’-deoxiguanozina
(8-OHdG), este un biomarker a stresului oxidativ, acumulata in
ADN cauzeaza disfunctia
mitocondriala si criza energetica
Disfunctia mitocondriala care este o caracteristica a celulelor maligne, datorat prin capacitatea scazuta antioxidativa.
| Antioxidantii apara celula de efectele oxigenului reactiv | Antioxidantii cu neutralizarea de radicali liberi - Capacitate scazuta antioxidativa |
 |
 |
- Antioxidanti se gasesc in orice celula, protejeaza
organismul de distrugerile provocate la nivel celular de radicalii
liberi.
- Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata,
daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa
- Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti
ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa
de efectele radicalilor liberi.
Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta
Sint o multime de antioxidanti in extracte de plante naturale, fitofarmaceutice, nutraceutice cu capacite de neutralizare a radicalilor liberi Antioxidanti cheie: Acid Alfa Lipoic, Coenzima Q10, Vitamine: Vitamina C, Vitamina E, Caretenoizi, (beta caroten,alfa caroten, licopen, luteina, zeaxantina) Compusi fenolici: Flavonoizi, polifenoli care confera protectie ridicata antoxidativa
- Suficienti antioxidanti de recomandat: Acid Alfa Lipoic, Ceai Verde EGCG, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H 2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
Spirulina contine
superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g
Suficienti antioxidanti de recomandat: Acid alfa lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta
EGCG cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C
24 In
procesul de imbatrinire duplicarea ADN-ului nu se copiaza toata secventa,
ci se pierde o bucatica din capatul cromozomului
(Telomere), Ceaiul Verde antioxidant puternic intirzie procesul de
imbatrinire (Anti Aging)
25 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% antioxidant puternic
un inhibitor
enzimei de telomeraza
Ceai Verde Supreme cu: Galatul de epigalocatechina extr. stand. 50% antioxidant puternic
26 Studiu
mecanizmului molecular in reglarea activitatii de telomeraza enzima
responsabila pentru multiplicarea
celulei oncogene
27 Ceai Verde cu polifenoli de catechine EGCG - Galatul de epigalocatechina extr. stand. 50% cu uz medicinal si aplicatii la cancer
28 Ceai Verde cu EGCG - Galatul de epigalocatechina extr.
stand. 50% cu efect anticarcinogenic
29 Ceai Verde cu polifenoli de catechine EGCG - Galatul de epigalocatechina extr. stand. 50% previne cancerul
30 Ceai Verde cu polifenoli de catechine EGCG - Galatul de epigalocatechina extr. stand. 50% inhiba cresterea tumorala
31 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% are capacitatea
de inhibare de enzima metaloproteinaza matricial -9(MMP-9) (cunoscut
ca Gelatinaza
B) si (Gelatinaza A) aceasta enzima detine un rol important pentru
invazia tumorala si metastazarea cancerului
Chimioterapia cu citostatice la cancer mamar are reactii adverse ca: Astenie fizica, risc de infectii, alopecie, reducerea de cortexul prefrontal si a volumului hipocampal, cu consecinta a reducerii memoriei, care a fost masurata cu scara inteligentei lui D. Wechsler de Masatoshi Inagaki, M.D., Ph.D studiu
Citostatice naturale fito-farmaceutice: Ceai Verde Supreme cu puritate si concentratie de: Polifenoli 90%, monomeri sai Catechine extr. stand. 70% - Epicatechingalat, Epigalocatechin, Epicatechin si EGCG - Galatul de epigalocatechina 50%, fara reactii adverse
32 Extractul EGCG -
Galatul de epigalocatechina extr. stand. 50% inhiba celulele oncogene
33 Ceai Verde antioxidant cu catechine EGCG - Galatul de epigalocatechina extr. stand. 50% un anticancer inhiba carcinogeneza
la
glanda mamara
34 Ceai Verde cu polifenoli, catechine, EGCG Galatul de
epigalocatechina in neoplazia mamara
35 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% inhiba proteolitic enzima
urokinaza si ornitin decarboxilaza, urokinaza este o enzima de care
se foloseste celula de cancer pentru a intra in tesutul sanatos si
a forma metastaze.
36 Extractul EGCG -
Galatul de epigalocatechina extr. stand. 50% inhiba si actioneaza regresia
de enzima ornitin decarboxilaza la celulele de cancer de prostata (PC-3)
si cancerul mamar
37 Ceai
Verde cu polifenoli de catechine EGCG -
Galatul de epigalocatechina extr. stand. 50% inhiba enzima ornitin decarboxilaza
la celulele de cancer de prostata (PC-3)
38 Ceai
Verde cu polifenoli de catechine EGCG -
Galatul de epigalocatechina extr. stand. 50% reduce enzima 5-alfa reductaza
este un agent citostatic natural, inhiba proliferarea celulelor canceroase
de prostata
39 Ceai Verde cu EGCG - Galatul
de epigalocatechina extr. stand. 50% inhiba glioblastoma
40 Antioxidantul polifenolic EGCG -
Galatul de epigalocatechina extr. stand. 50% previne riscul de melanom malign
(cancer de piele), reduce inflamatia razelor UVB
41 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% inhiba tumori la nivelul pielii
indus de virusul papiloma
uman
42 Ceai Verde cu EGCG - Galatul de epigalocatechina
extr. stand. 50% sinergic cu Sulindac sau Tamoxifen activitatea de preventie
la cancer de plamin pe linia
celulara PC-9
43 Ceai Verde cu polifenoli de catechine EGCG - Galatul de epigalocatechina
extr. stand. 50% un imunomodulator si de inhibare la cancer de plamin
44 Ceai Verde cu EGCG - Galatul de epigalocatechina
extr. stand. 50% din catechine inhiba carcinogeneza la intestin si ficat
45 Ceai Verde cu polifenoli de catechine EGCG - Galatul de epigalocatechina
extr. stand. 50% inhiba carcinogeneza gastrointestinala
46 Ceai Verde cu polifenoli de catechine EGCG - Galatul de epigalocatechina
extr. stand. 50% un anticancer - antiinflamatoare cu inhibitorii selectivi COX-2, inhibitori
in cresterea celulelor de cancer la prostata in vitro si vivo ca si Resveratrol, Quercitina, Curcumina, Capsaicina
Anticancer - Antiinflamatoare cu inhibitorii selectivi COX-2: EGCG, Resveratrol, Quercitina, Curcumina, Capsaicina
47 Ceai Verde cu polifenoli de catechine EGCG - Galatul de epigalocatechina
extr. stand. 50% un anticancer - antiinflamatoare cu inhibitorii selectivi COX-2, fara sa afecteze
COX-1 in expresia umana a celulelor de cancer la prostata ca si Resveratrol, Quercitina, Curcumina, Capsaicina
48 Ceai Verde cu polifenoli de catechine EGCG -
Galatul
de epigalocatechina extr. stand. 50% previne artrita
49 Ceai Verde cu EGCG - Galatul de epigalocatechina
extr. stand. 50% inhiba degradarea de cartilaj articular si colagen tip
II
50 Ceai Verde cu EGCG - Galatul de epigalocatechina
extr. stand. 50% atenueaza inflamatia la deficienta de interleukina-2
IL-2
51 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% cu potential de inhibare a IL-1beta
care induce catabolic efect in osteoartrita
52 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% in efectul antiinflamator
53 Ceai Verde cu EGCG - Galatul
de epigalocatechina extr. stand. 50% indicat in tromboza venoasa
Tromboza venoasa
54 EGCG
inhiba oxidarea colesterolului LDL
EGCG inhiba oxidarea colesterolului LDL
55 Ceai Verde cu EGCG - Galatul de epigalocatechina
extr. stand. 50% la hipercolestrolemia
56 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% la hipercolestrolemia mod de actiune
57 Ceai Verde cu EGCG - Galatul de epigalocatechina
extr. stand. 50% la bolile cardiovasculare si sanatate metabolica
58 Ceai Verde cu EGCG - Galatul
de epigalocatechina extr. stand. 50% cu actiune antioxidanta reduce
placa aterosclerotica, meta analiza
59 Ceai Verde cu EGCG -
Galatul de epigalocatechina extr. stand. 50% indicat la incidenta
de infarct miocardic si bolile cardiovasculare, studiu Rotterdam
60 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% flavonoid la riscul de boli coronariene
61 Consumul de Ceai Verde cu efect pozitiv, corelat cu reducerea mortalitatii indusa de bolile cardiovasculare,
cancer si alte cazuri, studiul Ohsaki
Consumul de EGCG cu efect pozitiv, corelat cu reducerea mortalitatii indusa de bolile cardiovasculare, cancer si alte cazuri
62 EGCG cu efect preventiv la incidenta vasculara cerebrala
63 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% indicat la gastrita
sau ulcer gastric
64 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% previne infectia cu
Helicobacter pilori
65 EGCG inhiba
infectia bacteriana cu Escherichia coli
66 Ceai Verde cu EGCG - Galatul
de epigalocatechina extr. stand. 50% are efect
terapeutic la infectia cu Legionella (Legionella pneumophila)
67 Ceai Verde cu EGCG - Galatul de epigalocatechina
extr. stand. 50% inhiba infectia de rotavirus si enterovirus
68 Ceai Verde cu EGCG - Galatul de epigalocatechina extr. stand. 50% inhiba infectia de influenta virus gripal de tip A si B
69 Ceai Verde un antioxidant cu polifenoli de catechine EGCG -
Galatul
de epigalocatechina extr. stand. 50% are actiune anti
- HIV
70
Ceai Verde cu EGCG - Galatul de epigalocatechina
extr. stand. 50% este un inhibitor nucleozidic de revers transcriptaza
71
EGCG
abroga efectiv endotoxina pentru sepsisul sever - HMGB1
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| Informatii din bibliografia electronica la tema: Nutritie si sanatate |
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